Research Groups

Asymmetric Cell Division and Ageing

Stem cells act in developing and adult organisms to produce the proper number of specialized cells in the body. When stem cells divide, they select a particular division mode that is symmetric or asymmetric. This division mode determines how many specialized and stem cell daughter cells are generated per stem cell division. As stem cells directly affect the future of the organism, it is essential that they choose a division mode that is appropriate for development, maintenance and repair of tissues. Defective division mode selection is implicated in developmental disorders, diseases such as cancer, and ageing.
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  • Judith Paridaen Visit
    Position

    Group Leader of the Laboratory of Asymmetric Cell Division and Ageing

    Research fields

    Neural Stem Cells, Asymmetric Cell Division, Neurogenesis, Cell Biology, Zebrafish Models, Mouse Models

    PhD Students
    Glòria Casas Gimeno
  • When making decisions on division mode and cell fates, stem cell integrate cell-intrinsic and -extrinsic signals and factors. Although several of these signals and factors have been identified, it is not clear how and when a stem cell selects its division mode and daughter cell fates. In our lab, we aim to understand how single stem cells make decisions on division mode and cell fates, and how these decisions affect developing and adult tissues. We employ single cell analyses, lineage tracing techniques and computational modeling to look at single stem cell behaviour in the developing and adult brain. We use the zebrafish and mouse as our main model systems. In particular, we are interested in the role of fate-determining factors such as signalling pathways and subcellular structures in symmetric and asymmetric stem cell divisions.
    • Paridaen JTML, Huttner WB. (2014). Neurogenesis during development of the vertebrate central nervous system. EMBO reports.
    • Paridaen JTML, Wilsch-Bräuninger M, Huttner WB. (2013) Asymmetric inheritance of centrosome-associated primary cilium membrane directs ciliogenesis after cell division. Cell.
    • Wilsch-Bräuninger M, Peters J, Paridaen JTML, Huttner WB. (2011) Basolateral rather than apical primary cilia on neuroepithelial cells committed to delamination. Development.
    • Paridaen JTML, Janson E, Utami KH, Pereboom TC, Essers PB, van Rooijen C, Zivkovic D, MacInnes AW. (2011) The nucleolar GTP-binding proteins Gnl2 and nucleostemin are required for retinal neurogenesis in developing zebrafish. Developmental Biology.
    • Paridaen JTML, Danesin C, Elas T, van de Water S, Houart C, Zivkovic D. (2009) Apc1 is required for maintenance of local brain organizers and dorsal midbrain survival. Dev Biol.
    • Paridaen JTML, Danesin C, Elas T, van de Water S, Houart C, Zivkovic D. (2009) Apc1-mediated antagonism of Wnt/β-catenin signaling is required for retino-tectal pathfinding in the zebrafish. Zebrafish.
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