Research Groups

Cellular senescence and age-related pathologies

The Demaria lab is interested to understand the function of a particular cell state, defined cellular senescence, in relation to aging. Our goal is to develop new interventions that target senescent cells to delay or prevent diseases associated with age.
  • People
  • Info
  • Publications
  • Marco Demaria Visit
    Position

    Group Leader of the Laboratory of Cellular Senescence and Age-related Pathologies

    Research fields

    Cellular Senecence, DNA damage, SASP, skin, aging, cancer, metastasis, chemotherapy, tissue repair, wound healing

    Postdoctoral Fellows
    Jaskaren Kohli
    PhD Students
    Alejandra Hernández Segura
    Jamil Nehme
    Abel Soto Gamez
    Nynke Talma
    Thijmen van Vliet
    Technicians
    Simone Brandenburg
  • Our group aims to dissect and isolate the molecular phenotypes of senescent cells induced by different stimuli, and to characterize how they can promote age-related pathology, including cancer. Cellular senescence is a complex tumor-suppressive mechanism induced by many different stresses characterized by growth arrest, changes in morphology and gene expression, and the secretion of inflammatory cytokines, proteases and other molecules that can alter the tissue microenvironment (a phenomenon termed the senescence-associated secretory phenotype or SASP). The Demaria lab has developed new tools to identify, isolate and characterize senescent cells in mice and humans, and to study how senescent cells participate in several biological processes. Using the skin as the reference tissue and a wide array of primary cells, mouse models and human biopsies, the lab will investigate the differences between beneficial and deleterious effects of cellular senescence with the long-term goal to develop new therapies for the prevention of age-related diseases and cancer
    • Hernandez-Segura A, de Jong TV, Melov S, Guryev V, Campisi J, Demaria M (2017) Unmasking Transcriptional Heterogeneity in Senescent Cells. Current Biology.
    • Jeon OH, Kim C, Laberge RM, Demaria M, Rathod S, Vasserot AP, Chung JW, Kim DH, Poon Y, David N, Baker DJ, van Deursen JM, Campisi J, Elisseeff JH. (2017) Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment. Nature Medicine.  
    • Soto-Gamez A, Demaria M. (2017) Therapeutic interventions for aging: the case of cellular senescence. Drug Discovery Today.
    • Demaria M, O'Leary MN, Chang J, Shao L, Liu S, Alimirah F, Koenig K, Le C Mitin N, Deal AM, Alston S, Academia EC, Kilmarx S, Valdovinos A, Wang B, de Bruin A, Kennedy BK, Melov S, Zhou D, Sharpless NE, Muss H, Campisi J. (2017) Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse. Cancer Discovery.    
    • Velarde MC, Demaria M. (2017) Targeting Senescent Cells: Possible Implications for Delaying Skin Aging: A Mini-Review. Gerontology.  
    • Loaiza N, Demaria M. (2016) Cellular senescence and tumor promotion: Is aging the key? Biochim Biophys Acta.  
    • Chang J, Wang Y, Shao L, Laberge RM, Demaria M, Campisi J, Janakiraman K, Sharpless NE, Ding S, Feng W, Luo Y, Wang X, Aykin-Burns N, Kragar K, Ponnappan U, Hauer-Jensen M, Meng A, Zhou D. (2015) Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice. Nature Medicine.
    • Liu S, Uppal H, Demaria M, Desprez PY, Campisi J, Kapahi P. (2015) Simvastatin suppresses breast cancer cell proliferation induced by senescent cells. Scientific Reports.
    • Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ. (2015) The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. Science.
    • Velarde M, Demaria M, Melov S, Campisi J. (2015) Pleiotropic age-dependent effects of mitochondrial dysfunction on epidermal stem cells. PNAS.
    • Laberge RM, Sun Y, Orjalo A, Patil C, Freund A, Zhou L, Curran S, Davalos A, Wilson-Edell K, Liu S, Limbad C, Demaria M, Li P, Hubbard G, Ikeno Y, Javors M, Desprez PY, Benz C, Kapahi P, Nelson P, Campisi J. (2015) mTOR Regulates the Tumor-Promoting Senescence-Associated Secretory Phenotype. Nature Cell Biology.
    • Christy B, Demaria M, Campisi J, Huang J, Dodds SG, Williams C, Hubbard G, Livi CB, Gao X, Weintraub S, Curiel T, Sharp ZD, Hasty P. (2015) p53 and Rapamycin are additive. Oncotarget.
    • Demaria M, Desprez PY, Campisi J, Velarde M. (2015) Cell autonomous and non-autonomous effects of senescent cells in the skin. Journal of Investigative Dermatology.
    • Neves J, Demaria M, Campisi J, Jasper H. (2015) Of flies, mice and men: evolutionary conserved tissue damage responses and aging. Developmental Cell.
    • Demaria M, Ohtani N, Youssef SA, Rodier F, Toussaint W, Mitchell JR, Laberge RM, Vijg J, Van Steeg H, Dollé M, Hoeijmakers J, deBruin A, Hara E, Campisi J. (2014) An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. Developmental Cell.
    • Chinta SJ, Woods G, Rane A, Demaria M, Campisi J, Andersen JK. (2014) Cellular senescence and the aging brain. Experimental Gerontology
    • Camporeale A, Demaria M, Monteleone E, Giorgi C, Wieckowski MR, Pinton P, Poli V. (2014) STAT3 activities and energy metabolism: dangerous liaisons. Cancers (Basel).
    • Demaria M, Camporeale A, Poli V. (2014) STAT3 and metabolism: how many ways to use a single molecule. International Journal of Cancer
    • Laberge RM, Adler D, Demaria M, Mechtouf N, Teachenor R, Cardin GB, Desprez PY, Campisi J, Rodier F. (2013) Mitochondrial DNA damage induces apoptosis in senescent cells. Cell Death & Disease
    • Chinta SJ, Lieu CA, Demaria M, Laberge RM, Campisi J, Andersen JK. (2013) Environmental stress, ageing and glial cell senescence: a novel mechanistic link to Parkinson's disease? Journal of Internal Medicine.
    • Velarde MC, Demaria M, Campisi J. (2013) Senescent cells and their secretory phenotype as targets for cancer therapy. Interdisciplinary Topics in Gerontology.
    • Demaria M, Campisi J. (2012) Matters of life and breath: A role for hypoxia in determining cell state. Aging Albany NY.
    • Demaria M, Poli V. (2012) PKM2, STAT3 and HIF-1α: The Warburg’s vicious circle. JAK-STAT.
    • Demaria M, Poli V. (2012) Pro-malignant properties of STAT3 during chronic inflammation. Oncotarget.
    • Laberge RM, Zhou L, Sarantos MR, Rodier F, Freund A, de Keizer PL, Liu S, Demaria M, Cong YS, Kapahi P, Desprez PY, Hughes RE, Campisi J. (2012) Glucocorticoids Suppress Selected Components of the Senescence-Associated Secretory Phenotype. Aging Cell.
    • Freund A, Laberge RM, Demaria M, Campisi J. (2012) Lamin B1 loss is a senescence-associated biomarker. Molecular Biology of the Cell.
    • Pensa S, Demaria M, Avalle L, Barbieri I, Camporeale A, Poli V. (2012) From tissue invasion to glucose metabolism: the many aspects of signal transducer and activator of transcription 3 pro-oncogenic activities. Hormone Molecular Biology and Clinical Investigation.
    • Demaria M, Misale S, Giorgi C, Miano V, Camporeale A, Campisi J, Pinton P, Poli V. (2012) STAT3 can serve as a hit in the process of malignant transformation of primary cells. Cell Death & Differentiation.
    • Haines B, Demaria M, Mao X, Xie L, Campisi J, Jin K, Greenberg DA. (2012) Hypoxia-inducible factor-1 and neuroglobin expression. Neuroscience Letter.
    • Demaria M, Poli V. (2011) From the nucleus to the mitochondria and back: the odyssey of a multitask STAT3. Cell Cycle.
    • Riess I,  Sala V,  Leo C, Demaria M, Gatti S, Gallo S, Fitou A, Boero O, Levi R, Cuccovillo I, Molla F, De Angelis N, Staszewsky  L, Latini R, Crepaldi T. (2011) A mouse model for spatial and temporal expression of HGF in the heart. Transgenic Research.
    • Demaria M, Giorgi C, Lebiedzinska M, Esposito G, D'Angeli L, Bartoli A, Gough DJ, Turkson J, Levy DE, Watson CJ, Wieckowski MR, Provero P, Pinton P, Poli V. (2010) A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction. Aging  Albany NY.
    • Barbieri I, Pensa S, Pannellini T, Quaglino E, Maritano D, Demaria M, Voster A, Turkson J, Cavallo F, Watson CJ, Provero P, Musiani P, Poli V. (2010) Constitutively active Stat3 enhances Neu-mediated migration and metastasis in mammary tumors via upregulation of Cten. Cancer Research.
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