Principal Investigators
Position Scientific Director, Group Leader of the Laboratory of Ageing Biology and Stem Cells
Research fields Hematopoietic stem cells, aging, leukemia, genetics, epigenetics
  • Research Profile
  • Selected Publications
  • Gerald de Haan received his MSc (1990) and PhD (1995) from the University of Groningen. As a graduate student he was employed by the University of Cologne, working on the regulation of blood cell production by growth factors. He became a postdoc at the University of Kentucky with Gary Van Zant where he worked on stem cell aging, and returned to the Netherlands as a fellow of the Royal Netherlands Academy of Sciences. He established his own lab at the Department of Cell Biology, where he was appointed full professor in 2005. He was awarded a VICI grant by the Netherlands Organization of Scientific Research in 2007. From October 2016 Gerald holds the position of Scientific Director of the European Research Institute for the Biology of Ageing.

    The general scope of studies in his Laboratory is to further improve the understanding of mechanisms that specify normal stem cell functioning. Studies focus on hematopoietic stem cells, largely because superior technical tools and invaluable functional assays exist to study stem cells in this particular tissue. Gerald’s group is interested in the unique genetic and epigenetic program that distinguishes stem cells from non-stem cells.[vimeo id=”52142397″

    • Edyta E. Wojtowicz, Eric R. Lechman, Karin G. Hermans, Erwin M. Schoof, Erno Wienholds, Ruth Isserlin, Peter A. van Veelen, Mathilde J.C. Broekhuis, George. M.C. Janssen, Aaron Trotman-Grant, Stephanie M. Dobson2, Gabriella Krivdova, Jantje Elzinga, James Kennedy, Olga Gan, Ankit Sinha, Vladimir Ignatchenko, Thomas Kislinger, Ellen Weersing, Mir Farshid Alemdehy, Hans W.J. de Looper, Bader, GD, Martha Ritsema, Stefan J. Erkeland, Leonid V. Bystrykh, John E. Dick2 and Gerald de Haan. (2016) Ectopic miR-125a Expression Induces Long-Term Repopulating Stem Cell Capacity in Mouse and Human Hematopoietic Progenitors. Cell Stem Cell.
    • Verovskaya E, Broekhuis MJ, Zwart E, Ritsema M, van Os R, de Haan G, Bystrykh LV. (2013) Heterogeneity of young and aged murine hematopoietic stem cells revealed by quantitative clonal analysis using cellular barcoding. Blood.
    • Geiger H, de Haan G and Florian MC. (2013) The ageing hematopoietic stem cell compartment. Nature Reviews Immunology.
    • Klauke K, Radulović V, Broekhuis M, Weersing E, Zwart E, Olthof S, Ritsema M, Bruggeman S, Wu X, Helin K, Bystrykh L, de Haan G. (2013) Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation. Nature cell biology.
    • Dykstra B, Olthof S, Schreuder J, Ritsema M, de Haan G. (2011) Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells. The journal of experimental medicine.
    • Kamminga LM, Bystrykh LV, de Boer A, Houwer S, Douma J, Weersing E, Dontje B, de Haan G. (2006) The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion. Blood.
    • Bystrykh L, Weersing E, Dontje B, Sutton S, Pletcher MT, Wiltshire T, Su AI, Vellenga E, Wang J, Manly KF, Lu L, Chesler EJ, Alberts R, Jansen RC, Williams RW, Cooke MP, de Haan G. (2005) Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'. Nature genetics.
    • de Haan G, Weersing E, Dontje B, van Os R, Bystrykh LV, Vellenga E, Miller G. (2003) In vitro generation of long-term repopulating hematopoietic stem cells by FGF-1. Developmental Cell.
    • de Haan G, Gelman R, Watson A, Yunis E, Van Zant G. (1998) A putative gene causes variability in lifespan among genotypically identical mice. Nature Genetics.
    • de Haan G and Van Zant G. (1997) Intrinsic and extrinsic control of hemopoietic stem cell numbers: mapping of a stem cell gene. Journal of Experimental Medicine.
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