|Position||Group Leader of the Laboratory of Macromolecules and Interactomes|
|Research fields||Human Interactomics, L1 Retrotransposons, and RNA Processing|
John LaCava earned a B.S. degree in Biotechnology from the University of California, Davis (2000). He subsequently earned his Ph.D. in Molecular Genetics (2005) from The University of Edinburgh, Scotland, where he studied mechanisms of post-transcriptional gene regulation with Prof. David Tollervey. Thereafter, as a visiting scientist, John trained in structural proteomic research methods within the Mass Spectrometry of Biomacromolecules group at the University of Amsterdam; and as an EMBO long term post-doctoral fellow, he studied pre-mRNA splicing regulation at the Centre for Genomic Regulation in Barcelona, Spain. In 2008, John returned to the USA to join the Laboratory of Cellular and Structural Biology at The Rockefeller University. Working with Profs. Michael Rout, Brian Chait, and others in the NIH-funded National Center for Dynamic Interactome Research, John focussed on developing methods to improve protein interactions studies. In 2016 John was promoted to the rank of Research Assistant Professor at The Rockefeller University and also joined Prof. Jef Boeke’s NIH-funded Center for Systems Biology of Retrotransposition, earning him a joint appointment as Visiting Assistant Professor at NYU Langone Health. In 2019 John was promoted to Research Associate Professor at The Rockefeller University, and was recruited to join ERIBA as a Principal Investigator, where he leads the Laboratory of Macromolecules and Interactomes. John’s group will focus, broadly, on the development and application of preparative and analytical approaches to study the contributions of dysregulated macromolecular interactions to human disease and aging-related pathologies; in particular, the group will also study the molecular pathophysiology of LINE-1 ribonucleoproteins in cancer and ageing.