Principal Investigators
Position Group Leader of the Laboratory of Asymmetric Cell Division and Ageing
Research fields Neural Stem Cells, Asymmetric Cell Division, Neurogenesis, Cell Biology, Zebrafish Models, Mouse Models
  • Research Profile
  • Selected Publications
  • Judith Paridaen obtained her PhD degree at the Hubrecht Institute for Stem Cell Research and Developmental Biology and Utrecht University in 2009. She worked in the lab of Dana Zivkovic on genetics of zebrafish brain development. Here, she uncovered novel functions of several genes in different aspect of brain development, such as regional patterning and neuronal differentiation. In 2009, she joined the lab of Prof. Wieland Huttner at the Max Planck Institute for Molecular Cell Biology and Genetics in Dresden, Germany. Here, she studied the cell biology of neural stem cells in the mouse embryo on a long-term EMBO post-doctoral fellowship. In her post-doctoral research, she discovered that inheritance of subcellular structures such as centrioles and primary cilia plays a role in asymmetric stem cell division in the developing mouse brain.

    In 2016, she joined the ERIBA as a Rosalind Franklin Fellow. Here, her lab studies the cell biological mechanisms that regulate stem cell division in developing and adult tissues. In particular, the group is interested in understanding how stem cells decide when and how to divide, and how they select daughter cell fates.

    • Paridaen JTML, Huttner WB. (2014). Neurogenesis during development of the vertebrate central nervous system. EMBO reports.
    • Paridaen JTML, Wilsch-Bräuninger M, Huttner WB. (2013) Asymmetric inheritance of centrosome-associated primary cilium membrane directs ciliogenesis after cell division. Cell.
    • Wilsch-Bräuninger M, Peters J, Paridaen JTML, Huttner WB. (2011) Basolateral rather than apical primary cilia on neuroepithelial cells committed to delamination. Development.
    • Paridaen JTML, Janson E, Utami KH, Pereboom TC, Essers PB, van Rooijen C, Zivkovic D, MacInnes AW. (2011) The nucleolar GTP-binding proteins Gnl2 and nucleostemin are required for retinal neurogenesis in developing zebrafish. Developmental Biology.
    • Paridaen JTML, Danesin C, Elas T, van de Water S, Houart C, Zivkovic D. (2009) Apc1 is required for maintenance of local brain organizers and dorsal midbrain survival. Dev Biol.
    • Paridaen JTML, Danesin C, Elas T, van de Water S, Houart C, Zivkovic D. (2009) Apc1-mediated antagonism of Wnt/β-catenin signaling is required for retino-tectal pathfinding in the zebrafish. Zebrafish.
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