Asymmetric Cell Division and Ageing

When making decisions on division mode and cell fates, stem cell integrate cell-intrinsic and -extrinsic signals and factors. Although several of these signals and factors have been identified, it is not clear how and when a stem cell selects its division mode and daughter cell fates.

In our research group, we aim to understand how individual stem cells make decisions on division mode and cell fates, and how these decisions affect developing and adult tissues. We employ single-cell analyses, lineage tracing techniques and live imaging to investigate individual neural stem cells and progenitors. We use the zebrafish developing brain as our main model system. In particular, we are interested in the role of fate-determining factors such as signaling pathways and subcellular structures in mediating the outcome of neural stem cell divisions.

• Paridaen JTML, Huttner WB. (2014). Neurogenesis during development of the vertebrate central nervous system. EMBO reports.
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• Paridaen JTML, Wilsch-Bräuninger M, Huttner WB. (2013) Asymmetric inheritance of centrosome-associated primary cilium membrane directs ciliogenesis after cell division. Cell.
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• Wilsch-Bräuninger M, Peters J, Paridaen JTML, Huttner WB. (2011) Basolateral rather than apical primary cilia on neuroepithelial cells committed to delamination. Development.
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• Paridaen JTML, Janson E, Utami KH, Pereboom TC, Essers PB, van Rooijen C, Zivkovic D, MacInnes AW. (2011) The nucleolar GTP-binding proteins Gnl2 and nucleostemin are required for retinal neurogenesis in developing zebrafish. Developmental Biology.
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• Paridaen JTML, Danesin C, Elas T, van de Water S, Houart C, Zivkovic D. (2009) Apc1 is required for maintenance of local brain organizers and dorsal midbrain survival. Dev Biol.
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• Paridaen JTML, Danesin C, Elas T, van de Water S, Houart C, Zivkovic D. (2009) Apc1-mediated antagonism of Wnt/β-catenin signaling is required for retino-tectal pathfinding in the zebrafish. Zebrafish.
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