PhD project on the nuclear pore complex and genome maintenance

We are looking for an enthusiastic and ambitious PhD candidate to work on a collaborative project involving the Veenhoff and Chang labs to study the role of the nuclear pore complex in maintaining genome stability.

The project

Genome instability is a hallmark of cancer and ageing. Intriguingly, the nuclear pore complexes (NPCs; the gateways between the nucleus and the cytoplasm) have been implicated in DNA replication and repair, as well as telomere maintenance. We aim to examine this topic on a molecular level using the budding yeast Saccharomyces cerevisiae as a model organism.

You are expected to conduct a research project involving a combination of yeast genetics, molecular biology, biochemistry, and live-cell imaging embedded within the research groups of Prof. Liesbeth Veenhoff (Laboratory of Cellular Biochemistry) and Dr. Michael Chang (Laboratory of Telomeres and Genome Integrity).

Working environment

The European Research Institute for the Biology of Aging (ERIBA) is a research institute within the University Medical Center Groningen (UMCG). ERIBA aims to discover molecular mechanisms of ageing that can be used as targets to prevent or delay age-related diseases. Our research teams are working with different model systems and technology platforms and share their knowledge and expertise to accelerate discoveries. ERIBA and the UMCG are located in Groningen, a vibrant student town in the northern Netherlands. PhD students are enrolled in the Graduate School of Medical Sciences of the University of Groningen.

What do we need

  • The applicants can be of any nationality.
  • The candidate should have an MSc in biomolecular sciences (or equivalent).
  • Applicants should be team-oriented, highly motivated, self-driven, and proficient in written and spoken English.

The UMCG has a preventive Hepatitis B policy. The UMCG can provide you with the vaccination, should it be required for your position.

In case of specific professions a ‘Certificate of Good Conduct’ is required.

What do we offer

  • An exciting research project.
  • Mentoring, supervision, and training.
  • Access to state-of-the art infrastructure.
  • A stimulating international research environment.
  • A competitive salary.

It concerns a fulltime appointment (36 hours a week) for a period of four years to be concluded with a PhD examination. After one year, the performance of the candidate will be evaluated to decide whether there is sufficient progress to expect a successful completion of the PhD thesis within the coming three years. Duration of the contract: one year with possibility for extension (funding available for four years).

Your salary will be a minimum of € 2.631,- gross per month in the first year and a maximum of € 3.336,- gross per month (scale PhD) in the final (4th) year, based on a full-time appointment. In addition, the UMCG will offer you 8% holiday pay, and 8.3% end-of-year bonus. The conditions of employment comply with the Collective Labour Agreement for Medical Centres (CAO-UMC).

More information:
The Chang lab
The Veenhoff lab
Groningen

For questions about the position

Any questions? Do contact us.

Dr. Michael Chang project leader

Prof. Liesbeth Veenhoff

You can apply until 14 September 2022.

Apply

 

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