C/EBPβ-LIP induces metabolic reprogramming by regulating the let-7/LIN28B circuit.
In this publication the Calkhoven lab shows that the C/EBPβ protein isoform LIP induces aerobic glycolysis and mitochondrial respiration, reminiscent of metabolism in cancer cells. LIP-induced metabolic programming is dependent on the RNA-binding protein LIN28B, a translational regulator of glycolytic and mitochondrial enzymes with known oncogenic function. LIP activates LIN28B through repression of the let-7 microRNA family that targets the Lin28b-mRNA. This study establishes LIP as an inducer of cancer-type metabolic reprogramming and as a regulator of the let-7/LIN28B regulatory circuit.
Ackermann T, Hartleben$ G, Müller C$, Mastrobuoni G, Groth M, Sterken BA, Zaini MA, Youssef SA, Zuidhof HR, Krauss SR, Kortman G, de Haan G, de Bruin A, Wang Z-Q, Platzer M, Kempa S, Calkhoven CF. (2019) C/EBPβ-LIP induces metabolic reprogramming by regulating the let-7/LIN28B circuit. Commun Biol, DOI: 10.1038/s42003-019-0461-z
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