p300 and SIRT1 regulated acetylation switch of C/EBPα controls mitochondrial function

This study led by the Calkhoven lab describes that the transcription factor C/EBPα is a key mediator of SIRT1-controlled transcription of mitochondrial genes, which results in increased mitochondrial respiration. SIRT1 is activated in times of energy demand by high levels of NAD+ and its activation is associated with increased health and lifespan. This work further reinforces the important role C/EBP transcription factors play in controlling energy homeostasis and related lifespan regulation.

Publication:

Mohamad A. Zaini, Christine Müller, Tristan V. de Jong, Tobias Ackermann, Götz Hartleben, Gertrud Kortman, Karl-Heinz Gührs, Fabrizia Fusetti, Oliver H. Krämer, Victor Guryev and Cornelis F. Calkhoven (2018). p300 and SIRT1 regulated acetylation switch of C/EBPα controls mitochondrial function. Cell Reports 22, 497-511.

https://doi.org/10.1016/j.celrep.2017.12.061