Unraveling the role of Neo1 and Netrin-1 in hematopoietic stem cell biology

Simon Renders from the German Cancer Research Center (DKFZ) together with PhD student Arthur Flohr Svendsen from the Ageing Biology and Stem Cells laboratory at ERIBA have describe the function of a gene firstly described in brain development – Neogenin-1 (Neo1) – in blood stem cells. In this recently study published they demonstrate how Neo1, together with its ligand Netrin-1, are important for blood stem cells to maintain their lifelong potential for self-renewal and its hole on the decline of the blood system.

https://www.eurekalert.org/pub_releases/2021-01/gcrc-hbs012521.php

https://www.nature.com/articles/s41467-020-20801-0