-
A novel flatworm-specific gene implicated in reproduction in Macrostomum lignano16 Feb. 2018This study by the Berezikov Group describes a novel direction for flatworm research. Flatworms are mainly known for being able to regenerate their complete body, including the germline. This is enabled by a population of stem cells, called neoblasts. Traditionally, molecular flatworm research focuse
-
p300 and SIRT1 regulated acetylation switch of C/EBPα controls mitochondrial function13 Feb. 2018This study led by the Calkhoven lab describes that the transcription factor C/EBPα is a key mediator of SIRT1-controlled transcription of mitochondrial genes, which results in increased mitochondrial respiration. SIRT1 is activated in times of energy demand by high levels of NAD+ and its activation
-
At the American Society for Hematology Meeting in Atlanta Gerald de Haan highlights common biologic concepts related to hematopoietic stem cell aging13 Feb. 2018http://www.bloodjournal.org/page/review-series/aging?sso-checked=true
-
Jaskaren Kohli awarded Marie-Curie Individual Fellowship09 Feb. 2018Jaskaren Kohli has been awarded a prestigious Marie-Curie Individual Fellowship by the European Union. He will be hosted by the Demaria laboratory to investigate what mechanisms underlie survival in senescent melanocytes, and whether interfering with these pathways can induce death of melanocytic
-
Research grant Gerald de Haan from LSBR12 Jan. 2018Gerald de Haan was awarded a research grant from the Landsteiner Foundation for Blood Transfusion Research (LSBR) to study the role of a novel cell surface receptor that his team has discovered to be preferentially expressed on very primitive hematopoietic stem cells. This receptor, Neogenin-1, is u
-
Defense Amr Zaini21 Dec. 2017December 11, Mohamad Amr Zaini successfully defended his PhD thesis, entitled “Post-transcriptional Control of C/EBPα and C/EBPβ Proteins – Insights into their role in energy homeostasis and disease” C/EBPα and C/EBPβ proteins are transcription factors playing important roles in the
-
Efficient transgenesis and annotated genome sequence of the regenerative flatworm model Macrostomum lignano14 Dec. 2017This collaborative effort led by scientists from the European Research Institute for the Biology of Ageing (ERIBA) describes the development of the transgenesis method and annotated genome sequence for the flatworm Macrostomum lignano. Flatworms are known for their amazing regenerative capabilities,
-
Mohamad Amr Zaini receives scientific presentation award06 Dec. 2017Mohamad Amr Zaini of the Calkhoven laboratory receives the scientific presentation award from Prof. Dr Björn Schumacher, the president of the German Foundation of Aging Research, which was held in Cologne, December 2-3. Cellular metabolism is a tightly controlled process in which the cell adapts fl
-
Exhaustive review Seka Lazare and Gerald de Haan24 Nov. 2017Seka Lazare and Gerald de Haan have written an exhaustive review on how stem cells that produce all the blood cells in our body lose functional potential during the aging process. This review was published in BLOOD, the leading journal in the field of Hematology. In the review they discuss molecular
-
Defense Hilda van den Bos08 Nov. 2017On Monday, the 23rd of October, Hilda van den Bos successfully defended her PhD thesis, entitled “Aneuploidy in the human brain and cancer. Studying heterogeneity using single-cell sequencing.” Thesis summary: Aneuploidy, an aberrant number of chromosomes in a cell, is a feature of several syndr