Ody Sibon’s research focuses on understanding the fundamental mechanisms underlying age-related neurodegeneration, with a particular emphasis on Coenzyme A (CoA) metabolism. Within the Sibon laboratory, research is directed at uncovering how disruptions in CoA biosynthesis contribute to rare neurological and cardiac diseases, including Pantothenate Kinase-Associated Neurodegeneration (PKAN). The lab applies a multidisciplinary approach, combining yeast, Drosophila melanogaster, mammalian cell systems, and mouse models to investigate how cells acquire, regulate, and utilize CoA.
A central aim of Ody Sibon’s work is to identify and characterize alternative pathways through which cells obtain CoA, challenging the traditional view that CoA is exclusively synthesized via vitamin B5-dependent pathways. The Sibon lab further explores how these mechanisms can be leveraged to develop novel therapeutic strategies. In addition, the group studies the interplay between host metabolism and the microbiome, with a particular focus on the exchange of CoA precursors between microbial communities and their host.
Overall, Ody Sibon’s research integrates fundamental and translational approaches, with the aim of advancing mechanistic insight and developing innovative treatments for CoA-related neurodegenerative and cardiac diseases .
Group leader of the Coenzyme A metabolism in health and disease
Coenzyme A (CoA) metabolism, Neuroacanthocytosis, Pantothenate Kinase-Associated Neurodegeneration (PKAN), Neurodegeneration & Brain iron metabolism
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