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Simon Renders from the German Cancer Research Center (DKFZ) together with PhD student Arthur Flohr Svendsen from the Ageing Biology and Stem Cells laboratory at ERIBA have describe the function of a gene firstly described in brain development – Neogenin-1 (Neo1) – in blood stem cells. In this re

In this study, Stijn Mouton and colleagues demonstrate that TIM29 is required for adapting to a highly proliferative state during regeneration in the flatworm Macrostomum lignano. In addition, they present how this model organism can be used to probe conserved genes with an unknown function for thei

A NWO-Open competition XS grant for groundbreaking projects was recently awarded to researcher Nynke Oosterhof in the group of Judith Paridaen. They will use this grant to develop a method to make a direct connection between in vivo imaging and single cell transcriptomics. If successful, this method

See the link for the article. Only in Dutch available.   https://kennisinzicht.umcg.nl/Paginas/Nobelprijs-voor-slim-schaartje-.aspx

Using an affinity capture-based interactome screen, John LaCava and colleagues demonstrated a detailed view of nuclear cap binding protein interactions (NCBP) in the ribonucleoprotein context. https://academic.oup.com/nar/article/48/18/10456/5909927#208177297

In a study published by John LaCava and colleagues, it was shown that the nuclear cap-binding protein 3 (NCBP3) primarily interacts with the components of the Exon junction complex (EJC) and the Transcription and Export Complex (TREX) to support mRNA expression https://academic.oup.com/nar/article/4

To properly function, the molecules in cells need a specific environment. Eriba researcher Sara Mouton and colleagues show that the characteristics of this environment changes with ageing. The researchers think this physicochemical aspect of ageing complements the traditional views of ageing that

A groundbreaking research project of the NWO open competition – XS has been awarded to Stijn Mouton. Stijn will use the immortal flatworm Schmidtea mediterranea to identify novel genes which are required for the maintenance of protein homeostasis. These genes will then be expressed in yeast to stu

Liesbeth will study the ‘Guardians of Protein Disorder’ with a cross disciplicary team of cell biologists, Steven Bergink and Harm Kampinga (UMCG), and physicists, Patrick Onck (ZIAM) and Cees Dekker (TuDelft)  

VICI grant awarded to Liesbeth Veenhoff! Liesbeth will study how and why a cell changes when it ages. Her research is aimed at revealing changes in the nuclear pores: the gatekeepers to the nucleus. This will contribute to discovery of the common cause of age-related diseases.