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UMCG’s ERIBA joins forces with the UK MSD Discovery Centre for boosting resilience to age-related neurodegeneration10 May. 2022UMCG’s ERIBA joins forces with the UK MSD Discovery Centre for boosting resilience to age-related neurodegeneration Researchers from the UMCG European Institute of Biological Ageing (ERIBA) recently started a collaboration with the MSD Discovery Centre in London. Together they will investigate the -
Enhanced C/EBPβ function promotes hypertrophic versus hyperplastic fat tissue growth and prevents steatosis in response to high-fat diet feeding26 Apr. 2022Christine Müller, Laura M. Zidek, Sabrina Eichwald, Gertrud Kortman, Mirjam H. Koster and Cornelis F. Calkhoven eLife 2022; 11: e62625 DOI: 10.7554/eLife.62625 Obesity is usually characterized by fat accumulation in enlarged – hypertrophic – adipocytes that are a source of inflammatory medi -
Marie Skłodowska-Curie Doctoral Network grant to Eugene Berezikov12 Apr. 2022REGENERATE-IT: learning from animals how to regenerate Eugene Berezikov received a Marie Skłodowska-Curie Doctoral Network (DN) grant and will coordinate the project entitled REGENERATE-IT, which brings together researchers working on different regenerative model organisms in order to understand -
C/EBPβ isoform-specific regulation of migration and invasion in triple-negative breast cancer cells18 Jan. 2022Britt A. Sterken, Tobias Ackermann, Christine Müller, Hidde R. Zuidhof, Gertrud Kortman, Alejandra Hernandez-Segura, Mathilde Broekhuis, Diana Spierings, Victor Guryev & Cornelis F. Calkhoven. C/EBPβ isoform-specific regulation of migration and invasion in triple-negative breast cancer cell -
KWF grant for Marco Demaria22 Dec. 2021The project done in the Demaria lab will explore sex-dependent differences in the accumulation of senescent cells in the liver and the relevance for development and progression of aggressive liver cancers. See link for more information: Ruim €1,7 miljoen van KWF voor 3 UMCG-onderzoeken &nbs -
Cor Calkhoven has received a grant from the Dutch Cancer Society (KWF)22 Dec. 2021Cor Calkhoven has received a grant from the Dutch Cancer Society (KWF). The proposed research aims to investigate the oncogenic mechanisms behind the upregulation of the transcription factor C/EBPβ-LIP in Triple-Negative Breast Cancer (TNBC) and its function in cancer immune evasion. See the link f
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Inspiration video sustainability challenge-Jennefer Beenen14 Dec. 2021Hanze University of Applied Sciences has integrated the “Sustainable Development Goals” into their education, research and operational management. End of October this year, the Institute for Life Science & Technology (ILST) started the ILST Sustainability Challenge during which students, tea -
The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma12 Nov. 2021A study by Bočkaj, Martini, and de Camargo Magalhães et al. Out now in PLoS Genetics – The discovery that mutations in histone H3 variants frequently occur in malignant pediatric glioma created great interest into the mechanism of transformation of these so-called oncohistones. Yet whereas m -
The cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation12 Oct. 2021How aging causes relatively common diseases such as Alzheimer’s and Parkinson’s is still a mystery. Since toxic structural changes in proteins are likely to be responsible, Pras et al. investigated biological mechanisms that could drive such changes. The authors made use of a modifying factor ca -
School Science Outreach project Knowlands presented05 Oct. 2021In the Knowlands project by the RUG Pre-University Academy (Scholierenakademie), short movie clips and lesson packages were developed to reach year 3 and 4 of pre-university high schools (VWO) and teach about research skills. In the project, University of Groningen scientists from the alpha, beta an
