Principal Investigators
Position Group Leader of the Laboratory of Stem Cell Regulation and Mechanisms of Regeneration
Research fields Stem cells, regeneration, ageing, flatworms, small RNAs
  • Research Profile
  • Selected Publications
  • Eugene Berezikov studied natural sciences at the Novosibirsk State University (Russia), specializing in molecular biology, and graduated with honors in 1997. He received PhD degree in cell biology from the Institute of Cytology and Genetics (Novosibirsk, Russia) in 2000. For his postdoctoral studies he joined the laboratory of Prof. Ronald Plasterk at Hubrecht Institute, where he developed a method for homologous gene targeting in C. elegans and performed series of works on discovery and characterization of small RNAs and microRNAs in particular.

    In 2007 he was appointed as a group leader at Hubrecht Institute and started to work with the flatworm Macrostomum lignano. This animal is emerging as a powerful model organism for research on regeneration, stem cell biology and ageing due to its high regeneration capacity, experimental accessibility and amenability to genetic manipulation. In order to investigate regulation of neoblasts – the stem cells of the animal – by small RNAs and other molecular pathways, Berezikov group is developing genomic tools and resources for M. lignano, including de novo genome sequencing and annotation, identification of neoblast markers, transgenics, and forward and reverse genetics methods.

    Eugene is an EMBO Young Investigator from 2010. In 2012, he was awarded with a 1,5M€ grant by the European Research Council for his research project on relations between stem cells and ageing using M. lignano as a model.


    • Mouton S, Grudniewska M, Glazenburg L, Guryev V, Berezikov E (2018) Resilience to aging in the regeneration-capable flatworm Macrostomum lignano. Aging Cell.  
    • Grudniewska M, Mouton S, Grelling M, Wolters AHG, Kuipers J, Giepmans BNG, Berezikov E (2018) A novel flatworm-specific gene implicated in reproduction in Macrostomum lignano. Scientific Reports.
    • Wudarski J, Simanov D, Ustyantsev K, de Mulder K, Grelling M, Grudniewska M, Beltman F, Glazenburg L, Demircan T, Wunderer J, Qi W, Vizoso DB, Weissert PM, Olivieri D, Mouton S, Guryev V, Aboobaker A, Schärer L, Ladurner P, Berezikov E.(2017) Efficient transgenesis and annotated genome sequence of the regenerative flatworm model Macrostomum lignano. Nature Communications  
    • Grudniewska M, Mouton S, Simanov D, Beltman F, Grelling M, de Mulder K, Arindrarto W, Weissert PM, van der Elst S, Berezikov E. (2016) Transcriptional signatures of somatic neoblasts and germline cells in Macrostomum lignano. Elife.  
    • Isik M, Blackwell TK, Berezikov E (2016) MicroRNA mir-34 provides robustness to environmental stress response via the DAF-16 network in C. elegans. Scientific Reports.
    • Ovchinnikova ES, Schmitter D, Vegter EL, ter Maaten JM, Valente MAE, Liu LCY, van der Harst P, Pinto YM, de Boer RA, Meyer S, Teerlink JR, O’Connor CM, Metra M, Davison BA, Bloomfield DM, Cotter G, Cleland JG, Mebazaa A, Laribi S, Givertz MM, Ponikowski P, van der Meer P, van Veldhuisen DJ, Voors AA*, Eugene Berezikov. (2015) Signature of circulating microRNAs in patients with acute heart failure. European Journal of Heart Failure.  
    • Junker JP, Noe ES, Guryev V, Peterson KA, Shah G, Huisken J,  McMahon AP, Berezikov E, Bakkers J, van Oudenaarden A. (2014) Genome-wide RNA Tomography. Cell.
    • Berezikov E. (2011) Evolution of microRNA diversity and regulation in animals. Nature Reviews Genetics.
    • de Wit E, Linsen SE, Cuppen E, Berezikov E. (2009) Repertoire and evolution of miRNA genes in four divergent nematode species. Genome Res.
    • Berezikov E, Guryev V, van de Belt J, Wienholds E, Plasterk RH, Cuppen E. (2005) Phylogenetic shadowing and computational identification of human microRNA genes. Cell.
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