Principal Investigators
Position Scientific Director of ERIBA and head of the Department
Research fields
  • Research Profile
  • Selected Recent Publications
  • Folkert Kuipers PhD (1957) will act as Scientific Director of ERIBA and head of the Department of the Biology of Ageing at the University Medical Center Groningen (UMCG) from August 1st, 2022. Folkert studied biology/biochemistry at the University of Groningen (UoG) and received his PhD degree in Medical Sciences at UoG in 1987. After a research fellowship from the Royal Netherlands Academy for Arts and Sciences and an Established Investigatorship from the Netherlands Heart Foundation, he was appointed as Professor of Pediatrics in 2000 and was Head of the Laboratory of Pediatrics at UMCG from 2000-2008 and 2016-2022. His research program deals with molecular (dys) regulation of cholesterol, bile acid and lipid metabolism and transport in liver and intestine in inherited and age-related metabolic diseases, including roles of the gut microbiome. He is (co-)author of >350 peer-reviewed publications and has supervised >40 PhD theses. From 2008-2016 he served as Dean of the Faculty of Medical Sciences/UMCG and was involved in initiation and implementation of the Healthy Ageing program at UMCG, with population cohort Lifelines and ERIBA as scientific flagship projects. He is member of the External Adivisory Boards of the Robert and Arlene Kogod Center for Aging Research, Mayo Clinic, Rochester, MN, USA, the Interdisciplinary Research Center on Longevity, Institut Pasteur de Lille, Lille, France, and the Multidisciplinary Institute for Ageing (MIA), University of Coimbra, Coimbra, Portugal.



    1. Li, A. Palmiotti, H.D. de Vries, M.V. Hovingh, M. Koehorst , N. L. Mulder, Y. Zhang, V. W. Bloks, J. Fu, H. J. Verkade, J.F. de Boer, F. Kuipers. Low production of 12α-hydroxylated bile acids prevents hepatic steatosis in mice with a human-like bile acid pool by reducing fat absorption. J Lipid Res, 62:100134, 2021
    2. Wang, M. Doestzada, L. Chen, S. Andreu-Sánchez, I.C.L. van den Munckhof, H. Augustijn, M. Koehorst, A.J. Ruiz-Moreno, V.W. Bloks, N.P. Riksen, J.H.W. Rutten, M.G. Netea, A. Zhernakova, F. Kuipers, J. Fu. Gut microbial structural variations as determinants of human bile acid metabolism. Cell Host & Microbe 8;29(12):1802-1814, 2021
    3. F. de Boer, H.D. de Vries, A. Palmiotti, R. Li, M. Doestzada, J.A. Hoogerland, J. Fu, A.M. La Rose, M. Westerterp, N.L. Mulder, M.V. Hovingh, M. Koehorst, N.J. Kloosterhuis, J.C. Wolters, V.W. Bloks, J.T. Haas, D. Dombrowicz, B. Staels, B. van de Sluis, F. Kuipers. Cholangiopathy and biliary fibrosis in Cyp2c70-deficient mice are fully reversed by ursodeoxycholic acid. Cellular and Molecular Gastroenterology and Hepatology, 11: 1045-1069, 2021
    4. Chen, I. C.L. van den Munckhof, K. Schraa, R. ter Horst, M. Koehorst, M. van Faassen, C. van der Ley, M. Doestzada, D.V. Zhernakova, A. Kurilshikov, V.W. Bloks, A.K. Groen, Human Functional Genomics Project, N.P. Riksen, J.H.W. Rutten, L.A.B. Joosten, C. Wijmenga, A. Zhernakova, M.G. Netea, J. Fu , F. Kuipers. Genetic and microbial associations to plasma and fecal bile acids in obese humans relate to plasma lipids and liver fat content Cell Reports 33(1):108212, 2020
    5. F. de Boer, M. Schonewille, M. Boesjes, H.Wolters, V. W. Bloks, T. Bos, T.H. van Dijk, A. Jurdzinski, R. Boverhof, J. M. van Deursen, R.P.J. Oude Elferink, A. Moschetta, C. Kremoser, H. J. Verkade, F. Kuipers, A.K. Groen. Intestinal FXR controls transintestinal cholesterol excretion in mice. Gastroenterology 152: 1126-1138, 2017


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