|Position||Group Leader of the Laboratory of Cellular Senescence and Age-related Pathologies|
|Research fields||Cellular Senecence, DNA damage, SASP, skin, aging, cancer, metastasis, chemotherapy, tissue repair, wound healing|
Dr Demaria obtained his PhD in Molecular Medicine at the University of Torino, Italy, under the supervision of prof. Valeria Poli. In Poli’s lab, he characterized the role of the transcription factor STAT3 as a master regulator of cancer cell survival and metabolism. He joined the laboratory of prof. Judith Campisi at the Buck Institute for Research on Aging, California USA, in the summer of 2010. In Campisi lab he developed tools and models to analyze senescent cells in vivo, and characterized the biological functions of senescent cells in tissue repair, cancer and aging. He also started to be interested in therapeutic approaches to target senescent cells to improve healthspan. He joined the University of Groningen and the European Research Institute for the Biology of Aging (ERIBA) in September 2015 as an Assistant Professor and Group leader of the laboratory “Cellular Senescence and Age-related Pathologies”. His research is focused towards identifying novel mechanisms and biomarkers associated to senescent cells. The laboratory has also a strong interest to characterize the pro-disease functions of senescent cells induced during aging and by anti-cancer therapies. A major goal is to exploit these findings for the development of rejuvenating interventions. In 2018 he co-founded a start-up company, Cleara Biotech, devoted to develop anti-senescence drugs. Dr Demaria also serves as academic editor for Aging Cell, Frontiers in Oncology and Plos One.