Principal Investigators
Position Group Leader of the Laboratory of Cellular Senescence and Age-related Pathologies
Research fields Cellular Senecence, DNA damage, SASP, skin, aging, cancer, metastasis, chemotherapy, tissue repair, wound healing
  • Research Profile
  • Selected Publications
  • Dr Demaria is an associate professor in Cellular Ageing. He obtained his PhD in Molecular Medicine at the University of Torino, Italy. Under the supervision of prof. Valeria Poli, he worked on the effect of chronic inflammation and cellular metabolism in tumor progression. In 2010, he joined the laboratory of prof. Judith Campisi at the Buck Institute for Research on Aging, California USA. In Campisi lab he developed tools and models to analyze senescent cells in vivo, and characterized the biological functions of senescent cells in tissue repair, cancer and aging. He also started to be interested in therapeutic approaches to target senescent cells to improve healthspan. He joined the University of Groningen and the European Research Institute for the Biology of Aging (ERIBA) in September 2015 as an Assistant Professor and Group leader of the laboratory “Cellular Senescence and Age-related Pathologies”. His research is focused towards identifying novel mechanisms and biomarkers associated to senescent cells. The laboratory has also a strong interest to characterize the pro-disease functions of senescent cells induced during aging and by anti-cancer therapies. A major goal is to exploit these findings for the development of rejuvenating interventions. In 2018 he co-founded a start-up company, Cleara Biotech, devoted to develop anti-senescence drugs. Dr Demaria serves as editor in chief for npj Aging and he is the President of the International Cell Senescence Association (ICSA).


    • Kohli J, Fitsiou E, Ge C, Wang B, Brandenburg SM, Diercks GFH, Faller WJ, Demaria M. (2022) Targeting anti-apoptotic pathways eliminates senescent melanocytes and leads to nevi regression. Nature Communcations.
    • Wang B, Varela-Eirin M, Brandenburg SM, Hernandez-Segura A, van Vliet T, Jongbloed EM, Wilting SM, Ohtani N, Jager A, Demaria M. (2022) Pharmacological CDK4/6 inhibition reveals a p53-dependent senescent state with restricted toxicities. EMBO Journal.
    • Nehme J, Yang D, Altulea A, Varela-Eirin M, Wang L, Hu S, Wu Y, Togo J, Niu C, Speakman JR, Demaria M. (2021) High protein and fat contents exacerbate hepatic senescence and SASP in mice. FEBS Journal.
    • Talma N, Gerrits E, Wang B, Eggen BJL, Demaria M.(2021) Identification of distinct and age-dependent p16High microglia subtypes. Aging Cell.
    • Kohli J, Wang B, Brandenburg SM et al. (2021) Algorithmic assessment of cellular senescence in experimental and clinical specimens. Nature Protocols.  
    • Vliet T, Wang B, Varela-Eirin M, Borghesan M, Brandenburg S, Evangelou K, Franzin R, Seelen M, Gorgoulis V, Demaria M.(2021) Physiological hypoxia restrains the Senescence-Associated Secretory Phenotype (SASP) via AMPK-mediated mTOR suppression. Molecular Cell.  
    • Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, Campisi J, Collado M, Evangelou K, Ferbeyre G, Gil J, Hara E, Krizhanovsky V, Jurk D, Maier AB, Narita M, Niedernhofer N, Passos JF, Robbins PD, Schmitt C, Sedivy J, Vougas K, von Zglinicki T, Zhou D, Serrano M, Demaria M.(2019) Cellular senescence: defining a path forward. Cell.  
    • Hernandez-Segura A, de Jong TV, Melov S, Guryev V, Campisi J, Demaria M (2017) Unmasking Transcriptional Heterogeneity in Senescent Cells. Current Biology.
    • Demaria M, O'Leary MN, Chang J, Shao L, Liu S, Alimirah F, Koenig K, Le C Mitin N, Deal AM, Alston S, Academia EC, Kilmarx S, Valdovinos A, Wang B, de Bruin A, Kennedy BK, Melov S, Zhou D, Sharpless NE, Muss H, Campisi J. (2017) Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse. Cancer Discovery.    
    • Demaria M, Ohtani N, Youssef SA, Rodier F, Toussaint W, Mitchell JR, Laberge RM, Vijg J, Van Steeg H, Dollé M, Hoeijmakers J, deBruin A, Hara E, Campisi J. (2014) An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. Developmental Cell.
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