|Position||Group leader of the Laboratory of Gene regulation in ageing and age-related diseases|
|Research fields||Transcriptional and post-transcriptional gene regulation, cancer, metabolism, ageing, lifespan determination|
Cor Calkhoven studied biology and chemistry at the University of Groningen. At this university he earned his PhD with the isolation and study of C/EBP transcription factors, which laid the foundation for his current work on C/EBP functions in ageing, cancer and metabolism. In 1996, Cor moved to the Max Delbrück Center for Molecular Medicine (MDC) in Berlin, with a Marie Curie Postdoctoral fellowship. In 2000, he was rewarded with a Helmholtz fellowship to start his own research group. At the MDC, he identified mRNA-regulatory elements that control translation of key factors in cellular differentiation and cancer. In 2005, Cor moved to the Leibniz Institute on Aging – Fritz Lipmann Institute (FLI), in Jena, where his lab developed a research interest in the shared regulatory mechanisms of ageing, metabolism and cancer. In 2013, Cor’s lab joined ERIBA to continue studying the molecular basis of ageing and age-related diseases.The current focus of his lab is on nutrient-mTORC1-C/EBP signaling pathways, oncogenic functions of C/EBP and mTORC1 as well as mRNA-modifications in cancer and ageing.