Principal Investigators
Position Group Leader of the Laboratory of Genome Structure and Ageing
Research fields Genomics, Bioinformatics
  • Research Profile
  • Selected Publications
  • Victor Guryev was trained as molecular biologist at Novosibirsk State University and received his PhD from Institute of Cytology and Genetics (Novosibirsk, Russia) in 2002. As a postdoc he joined groups of Prof. Ronald Plasterk and Dr. Edwin Cuppen at Hubrecht Institute to work on discovery and characterization of natural and induced genetic differences in model organism (rat, zebrafish, C. elegans) and characterization of their haplotype structure. Since 2006 his primary interest has been in functional consequences of structural changes in genomes. He constructed the first map of copy-number variants in rat and showed their effect on gene expression. Fascinated by structural plasticity of mammalian genomes, he combines his bioinformatics expertise and recent technological advances, such as high-throughput sequencing, to investigate dynamics of genome changes in populations and individual organisms. He is involved in several projects studying small- and large-scale genome structure variations in human and laboratory rat populations. Victor is currently a faculty member of Netherlands Bioinformatics Centre (NBIC) and was the head of bioinformatics at Hubrecht Institute until summer 2012.

    At ERIBA, Victor’s research is focused on studying changes of structural genome variation and its role in ageing.


    • Tristan V. de Jong,1 Yuri M. Moshkin,2,3* and Victor Guryev1* (2019), Gene expression variability: the other dimension in transcriptome analysis. Physiological Genomics
    • Mouton S, Grudniewska M, Glazenburg L, Guryev V, Berezikov E. Resilience to aging in the regeneration-capable flatworm Macrostomum lignano. (2018) Aging Cell.
    • Sin O, de Jong T, Kudron M , Zaini A , Aprile FA , Seinstra R, Mata-Cabana A, Stroo E, Willinge Prins R, Martineau C, Wang HH, Hogewerf W, Steinhof A, Wanker EE, Vendruscolo M, Calkhoven CF, Reinke V, Guryev V, Nollen EAA. (2017) Identification of an RNA Pol III-associated regulator of small non-coding RNAs that is linked with disease-associated protein agregation. Molecular Cell.
    • Hehir-Kwa JY, Marschall T, Kloosterman WP, Francioli LC, Baaijens JA, Dijkstra LJ, Abdellaoui A, Koval V, Thung DT, Wardenaar R, Renkens I, Coe BP, Deelen P, de Ligt J, Lameijer EW, van Dijk F, Hormozdiari F, The Genome of the Netherlands Consortium, Uitterlinden AG, van Duijn CM, Eichler EE, de Bakker PIW, Swertz MA, Wijmenga C, van Ommen GB, Slagboom PE, Boomsma DI, Schönhuth A, Ye K, Guryev V. (2016) A high-quality human reference panel reveals the complexity and distribution of genomic structural variants. Nature Communications.
    • Porubský D, Sanders AD, van Wietmarschen N, Falconer E, Hills M, Spierings DC, Bevova MR, Guryev V, Lansdorp PM. (2016) Direct chromosome-length haplotyping by single-cell sequencing. Genome Research.
    • Kloosterman WP, Francioli LC, Hormozdiari F, Marschall T, Hehir-Kwa JY, Abdellaoui A, Lameijer E-W, Moed MH, Koval V, Renkens I, van Roosmalen MJ, Arp P, Karssen LC, Coe BP, Handsaker RE, Suchiman ED, Cuppen E, Thung DT, McVey M, Wendl MC, Uitterlinden A, van Duijn CM, Swertz MA, Wijmenga C, van Ommen GB, Slagboom PE, Boomsma DI, Schönhuth A, Eichler  EE, de Bakker PIW, Ye K, Guryev V. (2015)  Characteristics of de novo structural changes in the human genome. Genome Research.
    • Kampen KR, Ter Elst A, Mahmud, H, Scherpen FJG, Diks SH, Peppelenbosch MP, de Haas V, Guryev V, de Bont ESJM. (2013) Insights in dynamic kinome reprogramming as a consequence of MEK inhibition in MLL-rearranged AML. Leukemia.
    • Low TY, van Heesch S, van den Toorn H, Giansanti P, Cristobal A, Toonen P, Schafer S, Hübner N, van Breukelen B, Mohammed S, Cuppen E, Heck AJ, Guryev V. (2013) Quantitative and qualitative proteome characteristics extracted from in-depth integrated genomics and proteomics analysis. Cell Reports.
    • van Heesch S, Mokry M, Boskova V, Junker W, Mehon R, Toonen P, de Bruijn E, Shull JD, Aitman TJ, Cuppen E, Guryev V. (2013) Systematic biases in DNA copy number originate from isolation procedures. Genome Biology.
    • Kloosterman WP, Guryev V, van Roosmalen M, Duran KJ, de Bruijn E, Bakker SC, Letteboer T, van Nesselrooij B, Hochstenbach R, Poot M, Cuppen E. (2011) Chromothripsis as a mechanism driving complex de novo structural rearrangements in the germline. Human molecular genetics.
    • Pontier DB, Kruisselbrink E, Guryev V, Tijsterman M.. (2009) Isolation of deletion alleles by G4 DNA-induced mutagenesis. Nature Methods.
    • Guryev V, Saar K, Adamovic T, Verheul M, van Heesch SA, Cook S, Pravenec M, Aitman T, Jacob H, Shull JD, Hubner N, Cuppen E. (2008) Distribution and functional impact of DNA copy number variation in the rat. Nature genetics.
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