Principal Investigators
Position Group Leader of the Laboratory of Cellular Biochemistry
Research fields Nuclear envelope, nuclear pore complex, membrane protein traffic, yeast ageing
  • Research Profile
  • Selected Publications
  • Liesbeth Veenhoff received her PhD degree (cum laude) at the University of Groningen in 2001, under the supervision Prof. Bert Poolman, studying the mechanism of a bacterial sugar transport protein. As a HFSP- fellow she moved to the laboratory of cellular biology of Prof. Michael Rout at the Rockefeller University in New York. Here, she worked in a collaborative effort to determine the architecture of the Nuclear Pore Complex of baker’s yeast. The intricate structure of this molecular machine fascinated, and the richness of the biology of nuclear transport impressed. So, when moving back, she continued to work on this topic supported by a Veni (2004) and Vidi (2008) grant. In 2010 she moved to the UMCG as an assistant professor and joined ERIBA in 2012. Liesbeth Veenhoff is currently an associate professor, and was awarded a Vici grant in 2020. The role of nuclear transport in cellular aging is the central interest of her lab at ERIBA.


    • Mouton SN, Thaller DJ, Crane MM, Rempel IL, Terpstra OT, Steen A, Kaeberlein M, Lusk CP, Boersma AJ, Veenhoff LM. (2020) A physicochemical perspective of aging from single-cell analysis of pH, macromolecular and organellar crowding in yeast. Elife.
    • Rempel IL, Steen A, Veenhoff LM. (2020) Poor old pores-The challenge of making and maintaining nuclear pore complexes in aging. FEBS J.  
    • Rempel IL, Popken P, Ghavami A, Mishra A, Hapsari RA, Wolters AHG, VeldsinkAC, Klaassens M, Meinema AC, Poolman B, Giepmans BNG, Onck PR, Steen A, Veenhoff LM. (2019) Flexible and Extended Linker Domains Support Efficient Targeting of Heh2 to the Inner Nuclear Membrane. Structure.
    • Rempel IL, Crane MM, Thaller DJ, Mishra A, Jansen DP, Janssens G, Popken P, Akşit A, Kaeberlein M, van der Giessen E, Steen A, Onck PR, Lusk CP, Veenhoff LM. (2019) Age-dependent deterioration of nuclear pore assembly in mitotic cells decreases transport dynamics. Elife.  
    • Janssens GE, Veenhoff LM. (2016) The Natural Variation in Lifespans of Single YeastCells Is Related to Variation in Cell Size, Ribosomal Protein, and Division Time. PLoS One.
    • Janssens GE, Veenhoff LM. (2016) Evidence for the hallmarks of human aging inreplicatively aging yeast. Microb Cell.
    • Janssens GE, Meinema AC, González J, Wolters JC, Schmidt A, Guryev V, Bischoff R, Wit EC, Veenhoff LM, Heinemann M. (2015) Protein biogenesis machinery is a driver of replicative aging in yeast. ELife.
    • Kralt A, Jagalur NB, van den Boom V, Lokareddy RK, Steen A, Cingolani G, Fornerod M, Veenhoff LM. (2015) Conservation of inner nuclear membrane targeting sequences in mammalian Pom121 and yeast Heh2 membrane proteins. Molecular Biology of the Cell.
    • Popken P, Ghavami A, Onck PR, Poolman B, Veenhoff LM. (2015) Size-dependent leak of soluble and membrane proteins through the yeast nuclear pore complex. Molecular Biology of the Cell.
    • Meinema AC, Laba JK, Hapsari RA, Otten R, Mulder FA, Kralt A, van den Bogaart G, Lusk CP, Poolman B, Veenhoff LM. (2011) Long unfolded linkers facilitate membrane protein import through the nuclear pore complex. Science.
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