Principal Investigators
Position Group Leader of the Laboratory of Telomeres and Genome Integrity
Research fields Telomeres, telomerase, DNA replication, DNA recombination, DNA damage, yeast
  • Research Profile
  • Selected Publications
  • Michael Chang received his PhD degree at the University of Toronto in 2005 under the supervision of Dr. Grant W. Brown, studying DNA damage response pathways using high-throughput functional genomics. After his PhD, he took a position at the Swiss Institute for Experimental Cancer Research (ISREC) in Lausanne as a postdoctoral fellow in the lab of Dr. Joachim Lingner, whose research is focused on telomerase and chromosome end replication. During this time, he determined that the processivity of yeast telomerase is significantly enhanced at critically short telomeres in a manner dependent upon the ATM-ortholog Tel1.
    In 2008, Michael moved to the lab of Dr. Rodney Rothstein at the Columbia University Medical Center in New York. He has continued to study factors that regulate telomerase, including the effect of changes in dNTP pools on telomerase-mediated telomere length homeostasis.
    He has also become interested in telomerase-independent modes of telomere maintenance, termed ALT (for Alternative Lengthening of Telomeres). In yeast, ALT cells are called ‘survivors’ and maintain their telomeric DNA via recombination-based processes. Michael has discovered that long telomeres are preferentially extended in emerging survivors.

    Michael Chang joined ERIBA as an Assistant Professor in 2011 where he continues studying both telomerase-dependent and telomerase-independent telomere maintenance mechanisms.

    • Novarina D, Desai R, Vaisica JA, Ou J, Bellaoui M, Brown GW and Chang M. (2020) A Genome-Wide Screen for Genes Affecting Spontaneous Direct-Repeat Recombination in Saccharomyces cerevisiae. G3: Genes/Genomes/Genetics  
    • Novarina D, Janssens GE, Bokern K, Schut T, van Oerle NC, Kazemier HG, Veenhoff LM, Chang M (2020) A genome-wide screen identifies genes that suppress the accumulation of spontaneous mutations in young and aged yeast cells. Ageing Cell.  
    • Claussin C, Porubský D, Spierings DCJ, Halsema N, Rentas S, Guryev V, Lansdorp PM, and Chang M. (2017) Genome-wide mapping of sister chromatid exchange events in single yeast cells using Strand-seq. Elife.
    • Strecker J, Stinus S, Caballero MP, Szilard RK, Chang M, Durocher D (2017) A sharp Pif1-dependent threshold separates DNA double-strand breaks from critically short telomeres. Elife.  
    • Novarina D, Mavrova SN, Janssens GE, Rempel IL, Veenhoff LM, Chang M. (2017) Increased genome instability is not accompanied by sensitivity to DNA damaging agents in aged yeast cells. DNA repair.
    • Claussin C, Chang M. (2016) Multiple Rad52-mediated homology-directed repair mechanisms are required to prevent telomere attrition-induced senescence in Saccharomyces cerevisiae. PLoS Genetics.
    • Gupta A, Sharma S, Reichenbach P, Marjavaara L, Nilsson AK, Lingner J, Chabes A, Rothstein R, Chang M. (2013) Telomere length homeostasis responds to changes in intracellular dNTP pools. Genetics.
    • Chang M, Dittmar JC, Rothstein R. (2011) Long Telomeres are Preferentially Extended During Recombination-Mediated Telomere Maintenance. Nature Structural & Molecular Biology.
    • Chang M, Arneric M, Lingner J. (2007) Telomerase repeat addition processivity is increased at critically short telomeres in a Tel1-dependent manner in Saccharomyces cerevisiae. Genes & Development.
    • Chang M, Bellaoui M, Zhang C, Desai R, Morozov P, Delgado-Cruzata L, Rothstein R, Freyer GA, Boone C, Brown GW. (2005) RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complex. the EMBO Journal.
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