Principal Investigators
Position Group leader of the Laboratory of Gene regulation in ageing and age-related diseases
Research fields Transcriptional and post-transcriptional gene regulation, cancer, metabolism, ageing, lifespan determination
  • Research Profile
  • Selected Publications
  • Cor Calkhoven studied biology and chemistry at the University of Groningen in the lab of Dr. Geert AB, where he received his PhD. During his PhD-study he discovered a specific gene regulatory mechanism in cancer and metabolism that laid the foundation for his current work. In 1996, Cor moved to the lab of Prof. Achim Leutz, at the Max Delbrück Center for Molecular Medicine (MDC) in Berlin, with a Marie Curie Postdoctoral fellowship. In 2000, he was rewarded with a Helmholtz fellowship to start his own research group. At the MDC, he identified mRNA-regulatory elements that control translation of key factors in cellular differentiation and cancer. In 2005, Cor moved to the Leibniz Institute for Age Research – Fritz Lipmann Institute (FLI), in Jena, where his lab developed a research interest in the common regulatory mechanisms of ageing, metabolism and cancer. The current focus of his lab is understanding the mechanisms of gene-regulation that are controlled by the nutrient and energy sensitive mTORC1 signaling pathway, and its involvement in health, disease and lifespan determination. In 2013, Cor’s lab joined ERIBA to continue studying the molecular basis of ageing and age-related diseases.

    • Ackermann T, Hartleben G, Müller C, Mastrobuoni G, Groth M, Sterken BA, Zaini MA, Youssef SA, Zuidhof HR, Krauss SR, Kortman G, de Haan G, de Bruin A, Wang Z-Q, Platzer M, Kempa S, Calkhoven CF. (2019) C/EBPβ-LIP induces metabolic reprogramming by regulating the let-7/LIN28B circuit. Commun Biol.
    • Hartleben G, Müller C, Krämer A, Schimmel H, Zidek LM, Dornblut C, Winkler R, Eichwald S, Kortman G, Kosan C, Kluiver J, Petersen I, van den Berg A, Wang Z-Q, Calkhoven. CF. (2018) Tuberous sclerosis complex is required for tumor maintenance in MYC-driven Burkitt’s lymphoma. EMBO Journal.
    • Müller C, Zidek LM, Ackermann T, de Jong T, Liu P, Kliche V, Zaini MA, Kortman G, Harkema L, Verbeek DS, Tuckermann JP, von Maltzahn J, de Bruin A, Guryev V, Wang ZQ, Calkhoven CF. (2018) Reduced expression of C/EBPβ-LIP extends health- and lifespan in mice. Elife.
    • Zaini MA, Müller C, de Jong TV, Ackermann T, Hartleben G, Kortman G, Gührs KH, Fusetti F, Krämer OH, Guryev V and Calkhoven CF (2018) p300 and SIRT1 regulated acetylation switch of C/EBPα controls mitochondrial function. Cell Reports.
    • Zaini MA, Müller C, Ackermann T, Reinshagen J, Kortman G, Pless O, Calkhoven CF. (2017) A screening strategy for the discovery of drugs that reduce C/EBPβ-LIP translation with potential calorie restriction mimetic properties. Scientific Reports.
    • In K, Zaini MA, Müller C, Warren AJ, von Lindern M, Calkhoven CF. (2016) Shwachman-Bodian Diamond Syndrome (SBDS) Protein deficiency impairs translation re-initiation from C/EBPa and C/EBPb mRNAs. Nucleic Acids Research.
    • Zidek LM, Ackermann T, Hartleben G, Eichwald S, Kortman G, Kiehntopf M, Leutz A, Sonenberg N, Wang Z-Q, von Maltzahn J, Müller C, and Calkhoven CF. (2015) Deficiency in mTORC1-controlled C/EBPβ-mRNA translation improves metabolic health in mice. EMBO Reports.
    • Müller C, Bremer A, Schreiber S, Eichwald S, Calkhoven CF. (2010) Nucleolar retention of a translational C/EBPalpha isoform stimulates rDNA transcription and cell size. The EMBO Journal.
    • Wethmar K, Bégay V, Smink JJ, Zaragoza K, Wiesenthal V, Dörken B, Calkhoven CF, Leutz A. (2010) C/EBPbetaDeltauORF mice--a genetic model for uORF-mediated translational control in mammals. Genes & Development.
    • Calkhoven CF, Müller C, Leutz A. (2000) Translational control of C/EBPalpha and C/EBPbeta isoform expression. Genes & Development.
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