Cor Calkhoven

Cor Calkhoven studied biology and chemistry at the University of Groningen. At this university he earned his PhD with the isolation and study of C/EBP transcription factors, which laid the foundation for his current work on C/EBP functions in ageing, cancer and metabolism. In 1996, Cor moved to the Max Delbrück Center for Molecular Medicine (MDC) in Berlin, with a Marie Curie Postdoctoral fellowship. In 2000, he was rewarded with a Helmholtz fellowship to start his own research group. At the MDC, he identified mRNA-regulatory elements that control translation of key factors in cellular differentiation and cancer. In 2005, Cor moved to the Leibniz Institute on Aging – Fritz Lipmann Institute (FLI), in Jena, where his lab developed a research interest in the shared regulatory mechanisms of ageing, metabolism and cancer. In 2013, Cor’s lab joined ERIBA to continue studying the molecular basis of ageing and age-related diseases.The current focus of his lab is on nutrient-mTORC1-C/EBP signaling pathways, oncogenic functions of C/EBP and mTORC1 as well as mRNA-modifications in cancer and ageing.

• Ackermann T, Zuidhof HR, Müller C, Kortman G, Rutten MGS, Broekhuis MJC, Zaini MA, Hartleben G and Calkhoven CF.(2023) C/EBPβ-LIP mediated activation of the malate-aspartate shuttle sensitizes cells to glycolysis inhibition.Molecular Metabolism  
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• Zuidhof, H.R. and Calkhoven, C.F. (2022) Oncogenic and tumour-suppressive functions of FTO. Cancer Research.  
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• Müller C, Zidek LM, Eichwald S, Kortman G, Koster M and Calkhoven CF. (2022) Enhanced C/EBPβ function promotes hypertrophic versus hyperplastic fat tissue growth and prevents steatosis in response to high-fat diet feeding. eLife.  
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• Sterken BA, Ackermann T, Zuidhof HR, Kortman G, Hernandez-Segura A, Müller C, Broekhuis M, Spierings D, Gurvey V, and Calkhoven CF. (2022) C/EBPβ isoform-specific regulation of migration and invasion in triple-negative breast cancer cells. NPJ Breast Cancer.  
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• Niehrs C. and Calkhoven CF. (2020) The emerging role of C/EBPβ and epigenetic DNA methylation in ageing. Trends in Genetics.
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• Hartleben G, Müller C, Krämer A, Schimmel H, Zidek LM, Dornblut C, Winkler R, Eichwald S, Kortman G, Kosan C, Kluiver J, Petersen I, van den Berg A, Wang Z-Q, Calkhoven. CF. (2018) Tuberous sclerosis complex is required for tumor maintenance in MYC-driven Burkitt’s lymphoma. EMBO Journal.
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• Müller C, Zidek LM, Ackermann T, de Jong T, Liu P, Kliche V, Zaini MA, Kortman G, Harkema L, Verbeek DS, Tuckermann JP, von Maltzahn J, de Bruin A, Guryev V, Wang ZQ, Calkhoven CF. (2018) Reduced expression of C/EBPβ-LIP extends health- and lifespan in mice. Elife.
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• Zaini MA, Müller C, de Jong TV, Ackermann T, Hartleben G, Kortman G, Gührs KH, Fusetti F, Krämer OH, Guryev V and Calkhoven CF (2018) p300 and SIRT1 regulated acetylation switch of C/EBPα controls mitochondrial function. Cell Reports.
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• Zaini MA, Müller C, de Jong TV, Ackermann T, Hartleben G, Kortman G, Gührs KH, Fusetti F, Krämer OH, Guryev V and Calkhoven CF (2018) p300 and SIRT1 regulated acetylation switch of C/EBPα controls mitochondrial function. Cell Reports.  
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• Zidek LM, Ackermann T, Hartleben G, Eichwald S, Kortman G, Kiehntopf M, Leutz A, Sonenberg N, Wang Z-Q, von Maltzahn J, Müller C, and Calkhoven CF. (2015) Deficiency in mTORC1-controlled C/EBPβ-mRNA translation improves metabolic health in mice. EMBO Reports.
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