Principal Investigators
Position Group Leader of the Laboratory of Stem Cell Regulation and Mechanisms of Regeneration
Research fields Stem cells, regeneration, ageing, flatworms, small RNAs
  • Research Profile
  • Selected Publications
  • Research Profile

    Eugene Berezikov studied natural sciences at the Novosibirsk State University (Russia), specializing in molecular biology, and graduated with honors in 1997. He received PhD degree in cell biology from the Institute of Cytology and Genetics (Novosibirsk, Russia) in 2000. For his postdoctoral studies he joined the laboratory of Prof. Ronald Plasterk at Hubrecht Institute, where he developed a method for homologous gene targeting in C. elegans and performed series of works on discovery and characterization of small RNAs and microRNAs in particular.

    In 2007 he was appointed as a group leader at Hubrecht Institute and started to work with the flatworm Macrostomum lignano. This animal is emerging as a powerful model organism for research on regeneration, stem cell biology and ageing due to its high regeneration capacity, experimental accessibility and amenability to genetic manipulation. In order to investigate regulation of neoblasts – the stem cells of the animal – by small RNAs and other molecular pathways, Berezikov group is developing genomic tools and resources for M. lignano, including de novo genome sequencing and annotation, identification of neoblast markers, transgenics, and forward and reverse genetics methods.

    Eugene is an EMBO Young Investigator from 2010. In 2012, he was awarded with a 1,5M€ grant by the European Research Council for his research project on relations between stem cells and ageing using M. lignano as a model.


    • Grudniewska M, Mouton S, Simanov D, Beltman F, Grelling M, de Mulder K, Arindrarto W, Weissert PM, van der Elst S, Berezikov E. (2016) Transcriptional signatures of somatic neoblasts and germline cells in Macrostomum lignano. Elife.  
    • Ovchinnikova ES, Schmitter D, Vegter EL, ter Maaten JM, Valente MAE, Liu LCY, van der Harst P, Pinto YM, de Boer RA, Meyer S, Teerlink JR, O’Connor CM, Metra M, Davison BA, Bloomfield DM, Cotter G, Cleland JG, Mebazaa A, Laribi S, Givertz MM, Ponikowski P, van der Meer P, van Veldhuisen DJ, Voors AA*, Eugene Berezikov. (2015) Signature of circulating microRNAs in patients with acute heart failure. European Journal of Heart Failure.  
    • Babae N, Bourajjaj M, Liu Y, Van Beijnum JR, Cerisoli F, Scaria PV, Verheul M, Van Berkel MP, Pieters EHE, Van Haastert R, Yousefi A, Mastrobattista E, Storm G, Berezikov E, Cuppen E, Woodle M, Schaapveld RQJ, Prevost GP, Griffioen AW, Van Noort PI , Schiffelers RM (2014) Systemic miRNA-7 delivery inhibits tumor angiogenesis and growth in murine xenograft glioblastoma. Oncotarget.

    • Moroz LL, Kocot KM, Citarella MR, Dosung S, Norekian TP, Povolotskaya IS, Grigorenko AP, Dailey C, Berezikov E, et all. (2014) The ctenophore genome and the evolutionary origins of neural systems. Nature.
    • Lengerer B, Pjeta R, Wunderer J, Rodrigues M, Arbore R, Schärer L, Berezikov E, Hess MW, Pfaller K, Egger B, Obwegeser S, Salvenmoser W, Ladurner P. (2014) Biological adhesion of the flatworm Macrostomum lignano relies on a duo-gland system and is mediated by a cell type-specific intermediate filament protein. Frontiers in Zoology.
    • Moreno-Mateos MA, Barragán V, Torres B, Rodríguez-Mateo C, Méndez-Vidal C, Berezikov E, Mudduluru G, Allgayer H, Pintor-Toro JA. (2013) Novel small RNA expression libraries uncover hsa-miR-30b and hsa-miR-30c as important factors in anoikis resistance. RNA.
    • Isik M, Berezikov E. (2013) Biolistic transformation of Caenorhabditis elegans. Methods Molecular Biology.
    • Janicke T, Marie-Orleach L, De Mulder K, Berezikov E, Ladurner P, Vizoso DB, Schärer L. (2013) Sex allocation adjustment to mating group size in a simultaneous hermaphrodite. Evolution.
    • Demircan T, Berezikov E. (2013) The Hippo pathway regulates stem cells during homeostasis and regeneration of the flatworm Macrostomum lignano. Stem Cells and Development.
    • Leptidis S, El Azzouzi H, Lok SI, de Weger R, Olieslagers S, Kisters N, Silva GJ, Heymans S, Cuppen E, Berezikov E, De Windt LJ, da Costa Martins P. (2013) A deep sequencing approach to uncover the miRNOME in the human heart. PloS One.
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