Constantinos Demetriades

Dr. Constantinos Demetriades is a molecular cell biologist and a European Research Council (ERC) Grantee. Currently, he holds an Associate Professor position in ERIBA/UMCG in Groningen. Previously (2017-2025) he served as a Max Planck Research Group Leader at the MPI-AGE in Cologne. The work from his group investigates the molecular mechanisms of nutrient sensing, metabolic regulation, and cell growth control, focusing primarily on the cell biological processes and signaling networks that regulate—and are regulated by—mTOR. Previously, following the completion of his PhD studies with George Mosialos in Greece (2004-2009), he joined the group of Aurelio Teleman at the German Cancer Research Center (DKFZ Heidelberg) as a postdoctoral researcher (2010-2016). He has received grants from the ERC (StG & PoC), the DFG, the Minna-James-Heineman Foundation, FEBS, the Alexander Onassis Foundation, and the Alexander Fleming Institute, won the 2019 Walther Flemming Award from the German Society for Cell Biology, and served as a speaker at the World Economic Forum Annual Meeting 2019 in Davos and the 2019 Berlin Science Week.

• Acharya A., and Demetriades C., mTORC1 activity licenses its own release from the lysosomal surface. Molecular Cell. 2024 October 31. doi:10.1016/j.molcel.2024.10.008
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• Fernandes SA., Angelidaki D-D., Nüchel J., Pan J., Gollwitzer P., Elkis Y., Artoni F., Wilhelm S., Kovacevic-Sarmiento M., and Demetriades C., Spatial and Functional Separation of mTORC1 Signaling in Response to Different Amino Acid Sources. Nature Cell Biology. 2024 October 9. doi:10.1038/s41556-024-01523-7
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• Nicastro R., Brohée L., Alba J., Nüchel J., Figlia G., Kipschull S., Gollwitzer P., Romero-Pozuelo J., Fernandes SA., Lamprakis A., Vanni S., Teleman AA., De Virgilio C., and Demetriades C., Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor. Nature Cell Biology. 2023 August 10. doi:10.1038/s41556-023-01198-6
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• Artoni F., Grützmacher N., and Demetriades C., Unbiased Evaluation of Rapamycin’s Specificity as an mTOR Inhibitor. Aging Cell. 2023 May 24;e13888. doi:10.1111/acel.13888
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• Huang W., Kew C., Fernandes SA., Loerhke A., Han L., Demetriades C., and Antebi A., Decreased spliceosome fidelity and egl-8 intron retention inhibit mTORC1 signaling to promote longevity. Nature Aging. 2022 Sept 19. doi:10.1038/s43587-022-00275-z
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• Gollwitzer P., Grützmacher N., Wilhelm S., Kümmel D., and Demetriades C., A Rag GTPase Dimer Code Defines the Regulation of mTORC1 by Amino Acids. Nature Cell Biology. 2022 Sept 12;24: 1394-1406. doi:10.1038/s41556-022-00976-y
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• Fitzian K., Brückner A., Brohée L., Zech R., Antoni C., Kiontke S., Gasper R., Linard Matos AL., Beel S., Wilhelm S., Gerke V., Ungermann C., Nellist M., Raunser S., Demetriades C., Oeckinghaus A., and Kümmel D., TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation. Molecular Cell. 2021 Jul 1;81(13):2705-2721.e8. doi:10.1016/j.molcel.2021.04.019
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• Demetriades C., Doumpas N., and Teleman AA., Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2. Cell. 2014 February 13; 156(4):786-99. doi:10.1016/j.cell.2014.01.024
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