Principal Investigators
Position Group Leader of the Laboratory of Genomic Instability in Development and Disease
Research fields Mouse models for aneuploidy, spindle checkpoint, chromosomal instability, CIN, aneuploidy and cancer, aneuploidy and ageing
  • Research Profile
  • Selected Publications
  • Floris Foijer obtained his PhD degree at the Netherlands Cancer Institute in Amsterdam in 2006. His PhD research in the lab of Prof. Hein te Riele focused on alternative mechanisms of cell cycle arrest in cells that are predisposed to cancer. He uncovered a checkpoint in the G2 phase of the cell cycle that allows these cells to arrest, but also showed that when this arrest is alleviated, such cells become chromosomal unstable, thus predisposing them further to unconstrained proliferation. For his postdoc, funded by the Dutch Cancer Society (KWF fellow), Foijer went to the lab of Prof. Peter Sorger at Harvard Medical School in Boston, USA, where he pursued the link between cancer and chromosome instability further. In Prof. Sorger’s lab, he developed murine models for chromosomal instability in the skin and the mammary gland and developed an interest in high resolution intravital imaging. In 2008, the need for more sophisticated murine models for high resolution imaging led him to the lab of Prof. Allan Bradley, at the Wellcome Trust Sanger institute in Cambridge, UK, where he, funded by a EMBO long term fellowship, started engineering a murine model to track chromosomal instability in living animals over time.

    In 2011, Floris Foijer moved to ERIBA to start his own lab focusing on the in vivo consequences of chromosomal instability.

    • Bakker B, Taudt A, Belderbos ME, Porubsky D, Spierings DC, de Jong TV, Halsema N, Kazemier HG, Hoekstra-Wakker K, Bradley A, de Bont ES, van den Berg A, Guryev V, Lansdorp PM, Colomé-Tatché M, Foijer F. (2016) Single-cell sequencing reveals karyotype heterogeneity in murine and human malignancies. Genome Biology.
    • van den Bos H, Spierings DC, Taudt AS, Bakker B, Porubský D, Falconer E, Novoa C, Halsema N, Kazemier HG, Hoekstra-Wakker K, Guryev V, den Dunnen WF, Foijer F, Tatché MC, Boddeke HW, Lansdorp PM. (2016) Single-cell whole genome sequencing reveals no evidence for common aneuploidy in normal and Alzheimer’s disease neurons. Genome Biology.
    • Heijink AM, Blomen VA, Bisteau X, Degener F, Matsushita FY, Kaldis P, Foijer F, van Vugt MA. (2015) A haploid genetic screen identifies the G1/S regulatory machinery as a determinant of Wee1 inhibitor sensitivity. PNAS.
    • Simon JE, Bakker B, Foijer F. (2015) CINcere Modelling: What Have Mouse Models for Chromosome Instability Taught Us? Recent Results in Cancer Research.
    • Bakker B, van der Bos H, Lansdorp PM, Foijer F (2015) How to count chromosomes in a cell: An overview of current and novel technologies. Bioessays.
    • Oliveira VL, Foijer F. (2015) Better check late than never: The chromosome segregation checkpoint. Bioessays.
    • Foijer F, Xie SZ, Simon JE, Bakker PL, Conte N, Davis S, Kregel E, Jonkers J, Bradley A, Sorger PK. (2014) Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress. PNAS.
    • Foijer F, DiTommaso T, Donati G, Hautaviita K, Xie SZ, Heath E, Smyth I, Watt FM, Sorger PK, Bradley A. (2013) Spindle checkpoint deficiency is tolerated by murine epidermal cells but not hair follicle stem cells. PNAS.
    • Orth JD, Kohler RH, Foijer F, Sorger PK, Weissleder R, Mitchison TJ. (2011) Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics. Cancer research.
    • van Harn T, Foijer F, van Vugt M, Banerjee R, Yang F, Oostra A, Joenje H, te Riele H. (2010) Loss of Rb proteins causes genomic instability in the absence of mitogenic signaling. Genes & development.
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