Principal Investigators
Position Group Leader of the Laboratory of Cellular Biochemistry
Research fields Nuclear envelope, nuclear pore complex, membrane protein traffic, yeast ageing
  • Research Profile
  • Selected Publications
  • Liesbeth Veenhoff received her PhD cum laude in 2001 from the University of Groningen, the Netherlands. Her PhD, with Bert Poolman, is on the mechanism of transport of sugars by a bacterial transport protein, and has provided her with a solid background in biochemistry and membrane biology. As a HFSP- fellow she moved to the laboratory of cellular biology of Michael Rout at the Rockefeller University in New York. Here, she worked in a collaborative effort to determine the architecture of the Nuclear Pore Complex of baker’s yeast. The intricate structure of this molecular machine fascinated, and the richness of the biology of nuclear transport impressed. So, when moving back to the laboratory of Bert Poolman in 2003, she continued to work on the nuclear pore complex and nuclear envelope of yeast, first as a Veni and later as a Vidi fellow.

    Liesbeth Veenhoff is currently an associate​ professor at the UMCG. The role of nuclear transport in cellular aging, and in particular its function in regulating access to the inner membrane of the nuclear envelope, is the central interest of her lab at ERIBA.

     

    • Rempel IL, Steen A, Veenhoff LM. (2020) Poor old pores-The challenge of making and maintaining nuclear pore complexes in aging. FEBS J.  
    • Novarina D, Janssens GE, Bokern K, Schut T, van Oerle NC, Kazemier HG, Veenhoff LM, Chang M. (2019) A genome-wide screen identifies genes that suppress the accumulation of spontaneous mutations in young and aged yeast cells. Aging Cell.  
    • Rempel IL, Popken P, Ghavami A, Mishra A, Hapsari RA, Wolters AHG, VeldsinkAC, Klaassens M, Meinema AC, Poolman B, Giepmans BNG, Onck PR, Steen A, Veenhoff LM. (2019) Flexible and Extended Linker Domains Support Efficient Targeting of Heh2 to the Inner Nuclear Membrane. Structure.
    • Rempel IL, Crane MM, Thaller DJ, Mishra A, Jansen DP, Janssens G, Popken P, Akşit A, Kaeberlein M, van der Giessen E, Steen A, Onck PR, Lusk CP, Veenhoff LM. (2019) Age-dependent deterioration of nuclear pore assembly in mitotic cells decreases transport dynamics. Elife.  
    • Janssens GE, Veenhoff LM. (2016) The Natural Variation in Lifespans of Single YeastCells Is Related to Variation in Cell Size, Ribosomal Protein, and Division Time. PLoS One.
    • Janssens GE, Veenhoff LM. (2016) Evidence for the hallmarks of human aging inreplicatively aging yeast. Microb Cell.
    • Janssens GE, Meinema AC, González J, Wolters JC, Schmidt A, Guryev V, Bischoff R, Wit EC, Veenhoff LM, Heinemann M. (2015) Protein biogenesis machinery is a driver of replicative aging in yeast. ELife.
    • Laba JK, Steen A, Popken P, Chernova A, Poolman B, Veenhoff LM. (2015) Active Nuclear Import of Membrane Proteins Revisited. Cells.
    • Kralt A, Jagalur NB, van den Boom V, Lokareddy RK, Steen A, Cingolani G, Fornerod M, Veenhoff LM. (2015) Conservation of inner nuclear membrane targeting sequences in mammalian Pom121 and yeast Heh2 membrane proteins. Molecular Biology of the Cell.
    • Lokareddy RK, Hapsari RA, van Rheenen M, Pumroy RA, Bhardwaj A, Steen A, Veenhoff LM, Cingolani G. (2015) Distinctive Properties of the Nuclear Localization Signals of Inner Nuclear Membrane Proteins Heh1 and Heh2. Structure.
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