Principal Investigators
Position Group Leader of the Laboratory of Cellular Biochemistry
Research fields Nuclear envelope, nuclear pore complex, membrane protein traffic, yeast ageing
  • Research Profile
  • Selected Publications
  • Liesbeth Veenhoff received her PhD cum laude in 2001 from the University of Groningen, the Netherlands. Her PhD, with Bert Poolman, is on the mechanism of transport of sugars by a bacterial transport protein, and has provided her with a solid background in biochemistry and membrane biology. As a HFSP- fellow she moved to the laboratory of cellular biology of Michael Rout at the Rockefeller University in New York. Here, she worked in a collaborative effort to determine the architecture of the Nuclear Pore Complex of baker’s yeast. The intricate structure of this molecular machine fascinated, and the richness of the biology of nuclear transport impressed. So, when moving back to the laboratory of Bert Poolman in 2003, she continued to work on the nuclear pore complex and nuclear envelope of yeast, first as a Veni and later as a Vidi fellow.

    Liesbeth Veenhoff is currently an associate​ professor at the UMCG. The role of nuclear transport in cellular aging, and in particular its function in regulating access to the inner membrane of the nuclear envelope, is the central interest of her lab at ERIBA.

     

    • Janssens GE, Meinema AC, González J, Wolters JC, Schmidt A, Guryev V, Bischoff R, Wit EC, Veenhoff LM, Heinemann M. (2015) Protein biogenesis machinery is a driver of replicative aging in yeast. eLife.
    • Kralt A, Jagalur NB, van den Boom V, Lokareddy RK, Steen A, Cingolani G, Fornerod M, Veenhoff LM. (2015) Conservation of inner nuclear membrane targeting sequences in mammalian Pom121 and yeast Heh2 membrane proteins. Molecular Biology of the Cell.
    • Lokareddy RK, Hapsari RA, van Rheenen M, Pumroy RA, Bhardwaj A, Steen A,Veenhoff LM, Cingolani G. (2015) Distinctive Properties of the Nuclear Localization Signals of Inner Nuclear Membrane Proteins Heh1 and Heh2. Structure.
    • Popken P, Ghavami A, Onck PR, Poolman B, Veenhoff LM. (2015) Size-dependent leak of soluble and membrane proteins through the yeast nuclear pore complex. Molecular Biology of the Cell.
    • Kralt A, Carretta M, Mari M, Reggiori F, Steen A, Poolman B, Veenhoff LM. (2015) Intrinsically disordered linker and plasma membrane-binding motif sort Ist2 and Ssy1 to junctions. Traffic.
    • Ghavami A, Veenhoff LM, van der Giessen E, Onck PR. (2015) Probing the disordered domain of the nuclear pore complex through coarse-grained molecular dynamics simulations. Biophysical Journal.
    • Laba JK, Steen A, Veenhoff LM. (2014) Traffic to the inner membrane of the nuclear envelope. Current Opinion in Cell Biology.
    • Meinema AC, Poolman B, Veenhoff LM. (2013) Quantitative analysis of membrane protein transport across the nuclear pore complex. Traffic.
    • Meinema AC, Poolman B, Veenhoff LM. (2012) The transport of integral membrane proteins across the nuclear pore complex. Nucleus.
    • Meinema AC, Laba JK, Hapsari RA, Otten R, Mulder FA, Kralt A, van den Bogaart G, Lusk CP, Poolman B, Veenhoff LM. (2011) Long unfolded linkers facilitate membrane protein import through the nuclear pore complex. Science.
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