Principal Investigators
Position Group Leader of the Laboratory of Cellular Senescence and Age-related Pathologies
Research fields Cellular Senecence, DNA damage, SASP, skin, aging, cancer, metastasis, chemotherapy, tissue repair, wound healing
  • Research Profile
  • Selected Publications
  • Dr Demaria obtained his PhD in Molecular Medicine at the University of Torino, Italy, under the supervision of prof. Valeria Poli. In Poli’s lab, he characterized the role of the transcription factor STAT3 as a master regulator of cancer cell survival and metabolism.  He joined the laboratory of prof. Judith Campisi at the Buck Institute for Research on Aging, California USA, in the summer of 2010. In Campisi lab he developed tools and models to analyze senescent cells in vivo, and characterized the biological functions of senescent cells in tissue repair, cancer and aging. He also started to be interested in therapeutic approaches to target senescent cells to improve healthspan. He joined the University of Groningen and the European Research Institute for the Biology of Aging (ERIBA) in September 2015 as an Assistant Professor and Group leader of the laboratory “Cellular Senescence and Age-related Pathologies”. His research is focused towards identifying novel mechanisms and biomarkers associated to senescent cells. The laboratory has also a strong interest to characterize the pro-disease functions of senescent cells induced during aging and by anti-cancer therapies. A major goal is to exploit these findings for the development of rejuvenating interventions. In 2018 he co-founded a start-up company, Cleara Biotech, devoted to develop anti-senescence drugs. Dr Demaria also serves as academic editor for Aging Cell, Frontiers in Oncology and Plos One.

    • Fontana L, Mitchell SE, Wang B, Tosti V, van Vliet T, Veronese N, Bertozzi B, Early DS, Maissan P, Speakman JR, Demaria M (2018) The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon. Aging Cell.
    • Hernandez-Segura A, Nehme J, Demaria M (2018) Hallmarks of Cellular Senescence. Trends Cell Biology.  
    • Chinta SJ, Woods G, Demaria M, Rane A, Zou Y, McQuade A, Rajagopalan S, Limbad C, Madden DT, Campisi J, Andersen JK (2018) Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson's Disease. Cell Reports.  
    • Kohli J, Campisi J, Demaria M (2018) A novel suicide gene therapy for the treatment of p16Ink4a-overexpressing tumors. Oncotarget.  
    • Hernandez-Segura A, de Jong TV, Melov S, Guryev V, Campisi J, Demaria M (2017) Unmasking Transcriptional Heterogeneity in Senescent Cells. Current Biology.
    • Jeon OH, Kim C, Laberge RM, Demaria M, Rathod S, Vasserot AP, Chung JW, Kim DH, Poon Y, David N, Baker DJ, van Deursen JM, Campisi J, Elisseeff JH. (2017) Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment. Nature Medicine.  
    • Demaria M, O'Leary MN, Chang J, Shao L, Liu S, Alimirah F, Koenig K, Le C Mitin N, Deal AM, Alston S, Academia EC, Kilmarx S, Valdovinos A, Wang B, de Bruin A, Kennedy BK, Melov S, Zhou D, Sharpless NE, Muss H, Campisi J. (2017) Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse. Cancer Discovery.    
    • Chang J, Wang Y, Shao L, Laberge RM, Demaria M, Campisi J, Janakiraman K, Sharpless NE, Ding S, Feng W, Luo Y, Wang X, Aykin-Burns N, Kragar K, Ponnappan U, Hauer-Jensen M, Meng A, Zhou D. (2015) Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice. Nature Medicine.
    • Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ. (2015) The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. Science.
    • Demaria M, Ohtani N, Youssef SA, Rodier F, Toussaint W, Mitchell JR, Laberge RM, Vijg J, Van Steeg H, Dollé M, Hoeijmakers J, deBruin A, Hara E, Campisi J. (2014) An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. Developmental Cell.
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