Principal Investigators
Position Group Leader of the Laboratory of Cellular Senescence and Age-related Pathologies
Research fields Cellular Senecence, DNA damage, SASP, skin, aging, cancer, metastasis, chemotherapy, tissue repair, wound healing
  • Research Profile
  • Selected Publications
  • Dr Demaria obtained his PhD at the University of Torino, Italy, under the supervision of prof. Valeria Poli. In Poli’s lab, he characterized the role of the transcription factor STAT3 as a master regulator of cancer cell survival and metabolism. Fascinated by the hypothesis that senescent cells present in the tumor microenvironment can promote cancer progression through protein secretion, he joined the laboratory of prof. Judith Campisi at the Buck Institute for Research on Aging, California USA, in the summer of 2010. There, he used a newly developed mouse model to navigate through the complex phenotypes of senescent cells, and showed both positive and negative roles of cellular senescence in different physiological and pathological context. He also started to be interested in therapeutic approaches to target the negative aspect of senescent cells. He joined the ERIBA in September 2015 as the Principal Investigator of the laboratory “Cellular Senescence and Age-related Pathologies”.

    • Hernandez-Segura A, de Jong TV, Melov S, Guryev V, Campisi J, Demaria M (2017) Unmasking Transcriptional Heterogeneity in Senescent Cells. Current Biology.
    • Jeon OH, Kim C, Laberge RM, Demaria M, Rathod S, Vasserot AP, Chung JW, Kim DH, Poon Y, David N, Baker DJ, van Deursen JM, Campisi J, Elisseeff JH. (2017) Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment. Nature Medicine.  
    • Demaria M, O'Leary MN, Chang J, Shao L, Liu S, Alimirah F, Koenig K, Le C Mitin N, Deal AM, Alston S, Academia EC, Kilmarx S, Valdovinos A, Wang B, de Bruin A, Kennedy BK, Melov S, Zhou D, Sharpless NE, Muss H, Campisi J. (2017) Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse. Cancer Discovery.    
    • Chang J, Wang Y, Shao L, Laberge RM, Demaria M, Campisi J, Janakiraman K, Sharpless NE, Ding S, Feng W, Luo Y, Wang X, Aykin-Burns N, Kragar K, Ponnappan U, Hauer-Jensen M, Meng A, Zhou D. (2015) Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice. Nature Medicine.
    • Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ. (2015) The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. Science.
    • Velarde M, Demaria M, Melov S, Campisi J. (2015) Pleiotropic age-dependent effects of mitochondrial dysfunction on epidermal stem cells. PNAS.
    • Demaria M, Desprez PY, Campisi J, Velarde M. (2015) Cell autonomous and non-autonomous effects of senescent cells in the skin. Journal of Investigative Dermatology.
    • Demaria M, Ohtani N, Youssef SA, Rodier F, Toussaint W, Mitchell JR, Laberge RM, Vijg J, Van Steeg H, Dollé M, Hoeijmakers J, deBruin A, Hara E, Campisi J. (2014) An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. Developmental Cell.
    • Demaria M, Misale S, Giorgi C, Miano V, Camporeale A, Campisi J, Pinton P, Poli V. (2012) STAT3 can serve as a hit in the process of malignant transformation of primary cells. Cell Death & Differentiation.
    • Demaria M, Giorgi C, Lebiedzinska M, Esposito G, D'Angeli L, Bartoli A, Gough DJ, Turkson J, Levy DE, Watson CJ, Wieckowski MR, Provero P, Pinton P, Poli V. (2010) A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction. Aging  Albany NY.
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