|Position||Group Leader of the Laboratory of Cellular Senescence and Age-related Pathologies|
|Research fields||Cellular Senecence, DNA damage, SASP, skin, aging, cancer, metastasis, chemotherapy, tissue repair, wound healing|
Dr Demaria obtained his PhD at the University of Torino, Italy, under the supervision of prof. Valeria Poli. In Poli’s lab, he characterized the role of the transcription factor STAT3 as a master regulator of cancer cell survival and metabolism. Fascinated by the hypothesis that senescent cells present in the tumor microenvironment can promote cancer progression through protein secretion, he joined the laboratory of prof. Judith Campisi at the Buck Institute for Research on Aging, California USA, in the summer of 2010. There, he used a newly developed mouse model to navigate through the complex phenotypes of senescent cells, and showed both positive and negative roles of cellular senescence in different physiological and pathological context. He also started to be interested in therapeutic approaches to target the negative aspect of senescent cells. He joined the ERIBA in September 2015 as the Principal Investigator of the laboratory “Cellular Senescence and Age-related Pathologies”.