Principal Investigators
Position Group Leader of the Laboratory of Cellular Senescence and Age-related Pathologies
Research fields Cellular Senecence, DNA damage, SASP, skin, aging, cancer, metastasis, chemotherapy, tissue repair, wound healing
  • Research Profile
  • Selected Publications
  • Dr Demaria is an associate professor in Cellular Ageing. He obtained his PhD in Molecular Medicine at the University of Torino, Italy. Under the supervision of prof. Valeria Poli, he worked on the effect of chronic inflammation and cellular metabolism in tumor progression.  In 2010, he joined the laboratory of prof. Judith Campisi at the Buck Institute for Research on Aging, California USA. In Campisi lab he developed tools and models to analyze senescent cells in vivo, and characterized the biological functions of senescent cells in tissue repair, cancer and aging. He also started to be interested in therapeutic approaches to target senescent cells to improve healthspan. He joined the University of Groningen and the European Research Institute for the Biology of Aging (ERIBA) in September 2015 as an Assistant Professor and Group leader of the laboratory “Cellular Senescence and Age-related Pathologies”. His research is focused towards identifying novel mechanisms and biomarkers associated to senescent cells. The laboratory has also a strong interest to characterize the pro-disease functions of senescent cells induced during aging and by anti-cancer therapies. A major goal is to exploit these findings for the development of rejuvenating interventions. In 2018 he co-founded a start-up company, Cleara Biotech, devoted to develop anti-senescence drugs. Dr Demaria also serves as academic editor for Aging Cell.

    • Kohli J, Wang B, Brandenburg SM et al. (2021) Algorithmic assessment of cellular senescence in experimental and clinical specimens. Nature Protocols.  
    • Vliet T, Wang B, Varela-Eirin M, Borghesan M, Brandenburg S, Evangelou K, Franzin R, Seelen M, Gorgoulis V, Demaria M.(2021) Physiological hypoxia restrains the Senescence-Associated Secretory Phenotype (SASP) via AMPK-mediated mTOR suppression. Molecular Cell.  
    • Wiley CD, Sharma R, Davis SS, Lopez-Dominguez JA, Mitchell KP, Wiley S, Alimirah F, Kim DE, Payne T, Rosko A, Aimontche E, Deshpande SM, Neri F, Kuehnemann C, Demaria M, Ramanathan A, Campisi J. (2021) Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis. Cell Metabolism.  
    • Nehme J, Borghesan M, Mackedenski S, Bird TG, Demaria M. (2020) Cellular senescence as a potential mediator of Covid-19 severity in the elderly. Aging Cell.  
    • Borghesan M, Hoogaars WMH, Varela-Eirin M, Talma N, Demaria M. (2020) A senescence-centric view on aging: implications for longevity and disease. Trends in Cell Biology.  
    • Casciaro F, Borghesan M, Beretti F, Zavatti M, Bertucci E, Follo MY, Maraldi T, Demaria M. (2020) Prolonged hypoxia delays aging and preserved functionality of human amniotic fluid stem cells. Mechanisms of ageing and development.  
    • Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, Campisi J, Collado M, Evangelou K, Ferbeyre G, Gil J, Hara E, Krizhanovsky V, Jurk D, Maier AB, Narita M, Niedernhofer N, Passos JF, Robbins PD, Schmitt C, Sedivy J, Vougas K, von Zglinicki T, Zhou D, Serrano M, Demaria M.(2019) Cellular senescence: defining a path forward. Cell.  
    • Fontana L, Mitchell SE, Wang B, Tosti V, van Vliet T, Veronese N, Bertozzi B, Early DS, Maissan P, Speakman JR, Demaria M (2018) The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon. Aging Cell.
    • Demaria M, O'Leary MN, Chang J, Shao L, Liu S, Alimirah F, Koenig K, Le C Mitin N, Deal AM, Alston S, Academia EC, Kilmarx S, Valdovinos A, Wang B, de Bruin A, Kennedy BK, Melov S, Zhou D, Sharpless NE, Muss H, Campisi J. (2017) Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse. Cancer Discovery.    
    • Demaria M, Ohtani N, Youssef SA, Rodier F, Toussaint W, Mitchell JR, Laberge RM, Vijg J, Van Steeg H, Dollé M, Hoeijmakers J, deBruin A, Hara E, Campisi J. (2014) An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. Developmental Cell.
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